about
Control of PKA stability and signalling by the RING ligase praja2The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptorSpatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cellsIdentification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cellsA Role of myosin Vb and Rab11-FIP2 in the aquaporin-2 shuttleInhibitor of MYC identified in a Kröhnke pyridine libraryIdentification of ERGIC-53 as an intracellular transport receptor of alpha1-antitrypsin.Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitorsSystematic identification of signal integration by protein kinase A.In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRsQuantification of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo.Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.Gpr161 anchoring of PKA consolidates GPCR and cAMP signalingThe many faces of compartmentalized PKA signalosomes.PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.Removal of the carboxy terminus of the A2A-adenosine receptor blunts constitutive activity: differential effect on cAMP accumulation and MAP kinase stimulation.Impact of kinase activating and inactivating patient mutations on binary PKA interactions.High-affinity AKAP7delta-protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.Calcium-dependent binding of Myc to calmodulin.praja2 regulates KSR1 stability and mitogenic signalingCorrigendum: Impact of kinase activating and inactivating patient mutations on binary PKA interactions.Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation.Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling.Phosphorylation of Protein Kinase A (PKA) regulatory subunit RIα by Protein Kinase G (PKG) primes PKA for catalytic activity in cells.Targeting the Architecture of Deregulated Protein Complexes in Cancer.MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer.Counterregulation of cAMP-directed kinase activities controls ciliogenesis.Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells.Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.Systematic Quantification of GPCR/cAMP-Controlled Protein Kinase A InteractionsKinCon: Cell-based recording of full-length kinase conformationsHedgehog and Gpr161: Regulating cAMP Signaling in the Primary CiliumBRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS
P50
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Eduard Stefan
@ast
Eduard Stefan
@en
Eduard Stefan
@es
Eduard Stefan
@nl
Eduard Stefan
@sl
type
label
Eduard Stefan
@ast
Eduard Stefan
@en
Eduard Stefan
@es
Eduard Stefan
@nl
Eduard Stefan
@sl
prefLabel
Eduard Stefan
@ast
Eduard Stefan
@en
Eduard Stefan
@es
Eduard Stefan
@nl
Eduard Stefan
@sl
P108
P106
P1153
6603012156
P21
P31
P496
0000-0003-3650-4713