Structure of human Cdc45 and implications for CMG helicase function
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Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replicationArchaeal orthologs of Cdc45 and GINS form a stable complex that stimulates the helicase activity of MCMCMG-Pol epsilon dynamics suggests a mechanism for the establishment of leading-strand synthesis in the eukaryotic replisome.Cdc45-induced loading of human RPA onto single-stranded DNA.Eukaryotic Replicative Helicase Subunit Interaction with DNA and Its Role in DNA Replication.The RecJ2 protein in the thermophilic archaeon Thermoplasma acidophilum is a 3'-5' exonuclease that associates with a DNA replication complex.Cell division cycle 45 promotes papillary thyroid cancer progression via regulating cell cycle.Cryo-EM of dynamic protein complexes in eukaryotic DNA replication.Mechanisms and regulation of DNA replication initiation in eukaryotes.Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication.Eukaryotic DNA Replication Fork.From structure to mechanism-understanding initiation of DNA replication.Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.Arranging eukaryotic nuclear DNA polymerases for replication: Specific interactions with accessory proteins arrange Pols α, δ, and ϵ in the replisome for leading-strand and lagging-strand DNA replication.Two Archaeal RecJ Nucleases from Methanocaldococcus jannaschii Show Reverse Hydrolysis Polarity: Implication to Their Unique Function in Archaea.Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase.The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis.Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast.The ring-shaped hexameric helicases that function at DNA replication forks.The crystal structure of Pyrococcus furiosus RecJ implicates it as an ancestor of eukaryotic Cdc45.Architecture of the Saccharomyces cerevisiae Replisome.O-GlcNAc transferase associates with the MCM2-7 complex and its silencing destabilizes MCM-MCM interactionsKeap1-MCM3 interaction is a potential coordinator of molecular machineries of antioxidant response and genomic DNA replication in metazoaCrystal Structure of Cdc45 Suggests a Conformational Switch that May Regulate DNA Replication
P2860
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P2860
Structure of human Cdc45 and implications for CMG helicase function
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Structure of human Cdc45 and implications for CMG helicase function
@en
type
label
Structure of human Cdc45 and implications for CMG helicase function
@en
prefLabel
Structure of human Cdc45 and implications for CMG helicase function
@en
P2860
P50
P356
P1476
Structure of human Cdc45 and implications for CMG helicase function
@en
P2093
Aline C Simon
P2860
P2888
P356
10.1038/NCOMMS11638
P407
P577
2016-05-18T00:00:00Z