about
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repairA dual role for UVRAG in maintaining chromosomal stability independent of autophagyMre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityMre11 assembles linear DNA fragments into DNA damage signaling complexesDifferences in the DNA replication of unicellular eukaryotes and metazoans: known unknownsAn ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replicationCEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombinationGEMC1 is a TopBP1-interacting protein required for chromosomal DNA replicationRegulation of DNA replication by ATR: signaling in response to DNA intermediates.ATR and ATM regulate the timing of DNA replication origin firing.Role for non-proteolytic control of M-phase-promoting factor activity at M-phase exitAn ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signalingFanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaksATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaksCep63 and cep152 cooperate to ensure centriole duplicationRAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forksSingle-strand DNA gaps trigger an ATR- and Cdc7-dependent checkpoint.RNase H and postreplication repair protect cells from ribonucleotides incorporated in DNATipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppressionPlx1 is required for chromosomal DNA replication under stressful conditionsStructure of human Cdc45 and implications for CMG helicase functionDealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair.Polo-like kinase 1 reaches beyond mitosis--cytokinesis, DNA damage response, and development.Tipin/Tim1/And1 protein complex promotes Pol alpha chromatin binding and sister chromatid cohesion.Studying the DNA damage response using in vitro model systems.GEMC1 is a critical regulator of multiciliated cell differentiation.Brca2, Rad51 and Mre11: performing balancing acts on replication forks.Mechanisms of replication fork protection: a safeguard for genome stability.DNA replication and homologous recombination factors: acting together to maintain genome stability.Notch is a direct negative regulator of the DNA-damage response.Replication, checkpoint suppression and structure of centromeric DNA.ATM controls proper mitotic spindle structureMoonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51.Xenopus egg extract to study regulation of genome-wide and locus-specific DNA replication.Topoisomerase I poisoning results in PARP-mediated replication fork reversal.HMGA1 protein is a novel target of the ATM kinase.Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.Responding to chromosomal breakage during M-phase: insights from a cell-free system.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Vincenzo Costanzo
@ast
Vincenzo Costanzo
@en
Vincenzo Costanzo
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Vincenzo Costanzo
@nl
Vincenzo Costanzo
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type
label
Vincenzo Costanzo
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Vincenzo Costanzo
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Vincenzo Costanzo
@es
Vincenzo Costanzo
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Vincenzo Costanzo
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prefLabel
Vincenzo Costanzo
@ast
Vincenzo Costanzo
@en
Vincenzo Costanzo
@es
Vincenzo Costanzo
@nl
Vincenzo Costanzo
@sl
P106
P1153
6603395486
P21
P31
P496
0000-0002-2920-9508