Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification.
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Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathwaysAutophagy in lysosomal storage disordersPubertal growth and epiphyseal fusionExtracellular distribution of diffusible growth factors controlled by heparan sulfate proteoglycans during mammalian embryogenesisMechanisms and models of endoplasmic reticulum stress in chondrodysplasiaDeveloping therapeutic approaches for metachromatic leukodystrophyBoning up on autophagy: the role of autophagy in skeletal biologyTFEB links autophagy to lysosomal biogenesisNew insight on FGFR3-related chondrodysplasias molecular physiopathology revealed by human chondrocyte gene expression profilingCurcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy.Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritisSulfatase modifying factor 1-mediated fibroblast growth factor signaling primes hematopoietic multilineage development.Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders.Autophagy failure in Alzheimer's disease--locating the primary defect.High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.Sulfatases are determinants of alveolar formation.Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder.Autophagy in toxicology: self-consumption in times of stress and plenty.FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12-ATG5 conjugate, leading to the delay of cartilage development in achondroplasiaUsing transgenic reporters to visualize bone and cartilage signaling during development in vivo.Current understanding on the molecular basis of chondrogenesis.Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation.FGF signalling regulates bone growth through autophagy.Sulfated hydrogel matrices direct mitogenicity and maintenance of chondrocyte phenotype through activation of FGF signaling.Heparan sulfate proteoglycans regulate autophagy in Drosophila.About the importance of being desulfatedAutophagy gets to the bone.mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy.Epiphyseal fusion in the human growth plate does not involve classical apoptosis.A non-conserved miRNA regulates lysosomal function and impacts on a human lysosomal storage disorder.FGFR3 biology and skeletal disease.Cartilage-Specific Autophagy Deficiency Promotes ER Stress and Impairs Chondrogenesis in PERK-ATF4-CHOP-Dependent Manner.Tetrahydrohyperforin prevents articular cartilage degeneration and affects autophagy in rats with osteoarthritis.Aggrecan catabolism during mesenchymal stromal cellin vitrochondrogenesis
P2860
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P2860
Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Proteoglycan desulfation deter ...... ing endochondral ossification.
@en
type
label
Proteoglycan desulfation deter ...... ing endochondral ossification.
@en
prefLabel
Proteoglycan desulfation deter ...... ing endochondral ossification.
@en
P2093
P2860
P356
P1433
P1476
Proteoglycan desulfation deter ...... ing endochondral ossification.
@en
P2093
Emilio Arteaga-Solis
Gerard Karsenty
Marc D McKee
Qais Al Awqati
Raquel de Pablo
P2860
P304
P356
10.1101/GAD.1711308
P577
2008-10-01T00:00:00Z