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Thrombospondin-1: a physiological regulator of nitric oxide signaling

Thrombospondin-1: a physiological regulator of nitric oxide signaling

http://www.wikidata.org/entity/Q36926096

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Emerging functions of matricellular proteins CD47 regulates bone mass and tumor metastasis to bone Activated CD47 regulates multiple vascular and stress responses: implications for acute kidney injury and its management CD47 knockout mice exhibit improved recovery from spinal cord injury.Determination of the CD148-Interacting Region in Thrombospondin-1 PADPIN: protein-protein interaction networks of angiogenesis, arteriogenesis, and inflammation in peripheral arterial disease.Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration.Cardiac CD47 drives left ventricular heart failure through Ca2+-CaMKII-regulated induction of HDAC3.Thrombospondin-1 activation of signal-regulatory protein-α stimulates reactive oxygen species production and promotes renal ischemia reperfusion injury.Matricryptic sites control tissue injury responses in the cardiovascular system: relationships to pattern recognition receptor regulated events.Cellular, pharmacological, and biophysical evaluation of explanted lungs from a patient with sickle cell disease and severe pulmonary arterial hypertension CD36 deletion improves recovery from spinal cord injury.Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47.Chronic delivery of a thrombospondin-1 mimetic decreases skeletal muscle capillarity in mice Age-dependent regulation of skeletal muscle mitochondria by the thrombospondin-1 receptor CD47.Heparan sulfate modification of the transmembrane receptor CD47 is necessary for inhibition of T cell receptor signaling by thrombospondin-1.Thrombospondin-1: multiple paths to inflammation.Thrombospondin-1 acts as a ligand for CD148 tyrosine phosphatase.Subtle renal dysfunction and bleeding risk in atrial fibrillation: symmetric dimethylarginine predicts HAS-BLED score Therapeutic Targeting of CD47 to Modulate Tissue Responses to Ischemia and Radiation.Original insights on thrombospondin-1-related antireceptor strategies in cancer.Identification of TAX2 peptide as a new unpredicted anti-cancer agent.Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model.CD47 gene knockout protects against transient focal cerebral ischemia in mice The counteradhesive proteins, thrombospondin 1 and SPARC/osteonectin, open the tyrosine phosphorylation-responsive paracellular pathway in pulmonary vascular endothelia.Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis.Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.Interactions among stalk modules of thrombospondin-1.Thrombospondin-1/CD47 blockade following ischemia-reperfusion injury is tissue protective.Thrombospondins in the heart: potential functions in cardiac remodeling.The role of thrombospondins in wound healing, ischemia, and the foreign body reaction.Tendon healing and platelet-rich plasma therapies.Therapies using anti-angiogenic peptide mimetics of thrombospondin-1.Syndecans as modulators and potential pharmacological targets in cancer progression.MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus.Thrombospondin-1, free radicals, and the coronary microcirculation: the aging conundrum.Role of thrombospondin 1 in liver diseases.Angiogenesis and Proteinases: Influence on Vascular Morphogenesis, Stabilization and Regression.Antineoplastic agent busulfan regulates a network of genes related to coagulation and fibrinolysis.

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Thrombospondin-1: a physiological regulator of nitric oxide signaling

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D D Roberts

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J S Isenberg

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P2860

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

Interaction of alpha9beta1 integrin with thrombospondin-1 promotes angiogenesis

Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake

Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner

A thrombin-sensitive protein of human platelet membranes

Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2beta1-mediated platelet activation

Inhibition of angiogenesis by thrombospondin-1 is mediated by 2 independent regions within the type 1 repeats

Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3

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