about
Therapeutic antibodies, vaccines and antibodyomesAdvances in recombinant antibody manufacturingEarly implementation of QbD in biopharmaceutical development: a practical exampleBiochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutumOxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodiesTop-down mass spectrometry for the analysis of combinatorial post-translational modifications.Anti-idiotypic antibodies: a new approach in prion research.Chromatographic behaviour of monoclonal antibodies against wild-type amidase from Pseudomonas aeruginosa on immobilized metal chelates.Aggregation of a multidomain protein: a coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stressSite-specific protein transamination using N-methylpyridinium-4-carboxaldehyde.A new tool for monoclonal antibody analysis: application of IdeS proteolysis in IgG domain-specific characterization.Engineered Bispecific Antibodies with Exquisite HIV-1-Neutralizing Activity.MABGEL 1: first phase 1 trial of the anti-HIV-1 monoclonal antibodies 2F5, 4E10 and 2G12 as a vaginal microbicideAntibody-mediated targeting of iron oxide nanoparticles to the folate receptor alpha increases tumor cell association in vitro and in vivoComparability analysis of protein therapeutics by bottom-up LC-MS with stable isotope-tagged reference standards.IL-15:IL-15 receptor alpha superagonist complex: high-level co-expression in recombinant mammalian cells, purification and characterization.Bridging the gap: facilities and technologies for development of early stage therapeutic mAb candidatesWeak protein interactions and pH- and temperature-dependent aggregation of human Fc1.IgG Conformer's Binding to Amyloidogenic Aggregates.A Novel Human scFv Library with Non-Combinatorial Synthetic CDR Diversity.Characterization of a recombinant humanized anti-cocaine monoclonal antibody and its Fab fragment.Therapeutic antibodies against cancer.Charge Variants of an Avastin Biosimilar Isolation, Characterization, In Vitro Properties and Pharmacokinetics in RatMultifunctional Dendrimer-templated Antibody Presentation on Biosensor Surfaces for Improved Biomarker Detection.Alleviating nonlinear behavior of disulfide isoforms in the reversed-phase liquid chromatography of IgG2.Surrogate target cells expressing surface anti-idiotype antibody for the clinical evaluation of an internalizing CD22-specific antibody.Chromatographic analysis of the acidic and basic species of recombinant monoclonal antibodies.A novel approach for the simultaneous quantification of a therapeutic monoclonal antibody in serum produced from two distinct host cell lines.IgG1 thioether bond formation in vivo.RPLC of intact proteins using sub-0.5 μm particles and commercial instrumentation.Rapid quantitative analysis of monoclonal antibody heavy and light chain charge heterogeneityDiscovery and characterization of hydroxylysine in recombinant monoclonal antibodies.Complex mixtures of antibodies generated from a single production qualitatively and quantitatively evaluated by native Orbitrap mass spectrometry.Stability of IgG isotypes in serum.Assessing monoclonal antibody product quality attribute criticality through clinical studies.Engineering the variable region of therapeutic IgG antibodies.Ligand binding assays in the 21st century laboratory: recommendations for characterization and supply of critical reagents.Quality attributes of recombinant therapeutic proteins: an assessment of impact on safety and efficacy as part of a quality by design development approach.High-resolution MS for structural characterization of protein therapeutics: advances and future directions.Applications of capillary electrophoresis in characterizing recombinant protein therapeutics.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Heterogeneity of monoclonal antibodies.
@en
type
label
Heterogeneity of monoclonal antibodies.
@en
prefLabel
Heterogeneity of monoclonal antibodies.
@en
P2093
P356
P1476
Heterogeneity of monoclonal antibodies.
@en
P2093
Chris Chumsae
Dinesh Faldu
Georgeen Gaza-Bulseco
Hongcheng Liu
Joanne Sun
P304
P356
10.1002/JPS.21180
P407
P577
2008-07-01T00:00:00Z