about
Cryo-EM near-atomic structure of a dsRNA fungal virus shows ancient structural motifs preserved in the dsRNA viral lineage.The T=1 capsid protein of Penicillium chrysogenum virus is formed by a repeated helix-rich core indicative of gene duplication.DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome.Andes virus nucleocapsid protein interrupts protein kinase R dimerization to counteract host interference in viral protein synthesis.Sequence-non-specific effects of RNA interference triggers and microRNA regulators.Co-expression of miRNA targeting the expression of PERK, but not PKR, enhances cellular immunity from an HIV-1 Env DNA vaccine.Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFNAnalysis of PKR activation using analytical ultracentrifugationHigh affinity, dsRNA binding by disconnected interacting protein 1Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR.Molecular basis for an attenuated cytoplasmic dsRNA response in human embryonic stem cellsRegulation of innate immunity through RNA structure and the protein kinase PKR.RNA helical imperfections regulate activation of the protein kinase PKR: effects of bulge position, size, and geometry.HIV-1 replication and the cellular eukaryotic translation apparatusStructural analysis of adenovirus VAI RNA defines the mechanism of inhibition of PKR.The stress granule protein G3BP1 recruits protein kinase R to promote multiple innate immune antiviral responses.Stochastic receptor expression determines cell fate upon interferon treatment.The use of analytical sedimentation velocity to extract thermodynamic linkage.Heparin activates PKR by inducing dimerization.Mechanistic Analysis of Activation of the Innate Immune Sensor PKR by Bacterial RNAMechanistic characterization of the 5'-triphosphate-dependent activation of PKR: lack of 5'-end nucleobase specificity, evidence for a distinct triphosphate binding site, and a critical role for the dsRBD.Analysis of high-affinity binding of protein kinase R to double-stranded RNAActivation of PKR by RNA misfolding: HDV ribozyme dimers activate PKR.Ingestion of genetically modified yeast symbiont reduces fitness of an insect pest via RNA interference.Bacterial Riboswitches and Ribozymes Potently Activate the Human Innate Immune Sensor PKRActivation of PKR by short stem-loop RNAs containing single-stranded arms.Analysis of PKR structure by small-angle scattering.Double-stranded RNA binding by the human cytomegalovirus PKR antagonist TRS1Both helix topology and counterion distribution contribute to the more effective charge screening in dsRNA compared with dsDNA.RNA dimerization promotes PKR dimerization and activation.Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop.Discriminating Self and Non-Self by RNA: Roles for RNA Structure, Misfolding, and Modification in Regulating the Innate Immune Sensor PKRDomain interactions in adenovirus VAI RNA mediate high-affinity PKR binding.Multi-level regulation of cellular recognition of viral dsRNA.Human RNAi pathway: crosstalk with organelles and cells.Analysis of PKR-RNA interactions by sedimentation velocityThe integrated stress response.Endogenous Retroelements and the Host Innate Immune Sensors.Mechanism of Protein Kinase R Inhibition by Human Cytomegalovirus pTRS1.Enterovirus 71 induces dsRNA/PKR-dependent cytoplasmic redistribution of GRP78/BiP to promote viral replication.
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Mechanism of PKR Activation by dsRNA.
@en
type
label
Mechanism of PKR Activation by dsRNA.
@en
prefLabel
Mechanism of PKR Activation by dsRNA.
@en
P2093
P2860
P1476
Mechanism of PKR Activation by dsRNA.
@en
P2093
Eric Anderson
James L Cole
Jeffrey Lary
Peter A Lemaire
P2860
P304
P356
10.1016/J.JMB.2008.05.056
P407
P577
2008-05-29T00:00:00Z