NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding. - Wikidata - wikimedia - TriplyDB

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

http://www.wikidata.org/entity/Q36967455

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Force and Compliance Measurements on Living Cells Using Atomic Force Microscopy (AFM).Molecular characterisation of the caprine (Capra hircus) lymphocyte function-associated antigen-1 alpha subunit-encoding cDNA.An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.Structure of an integrin with an αI domain, complement receptor type 4 An internal ligand-bound, metastable state of a leukocyte integrin, α X β 2 Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state RGD-containing peptides inhibit fibrinogen binding to platelet alpha(IIb)beta3 by inducing an allosteric change in the amino-terminal portion of alpha(IIb)Structural basis of integrin regulation and signaling Small-molecule inhibitors of protein-protein interactions: progressing towards the dream A small molecule agonist of an integrin, alphaLbeta2.Dynamic shifts in LFA-1 affinity regulate neutrophil rolling, arrest, and transmigration on inflamed endothelium.Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes.Small molecule agonists of integrin CD11b/CD18 do not induce global conformational changes and are significantly better than activating antibodies in reducing vascular injury.Identification and characterization of a human monoclonal antagonistic antibody AL-57 that preferentially binds the high-affinity form of lymphocyte function-associated antigen-1.High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.Molecular mechanism of alpha2beta1 integrin interaction with human echovirus 1.Integrin α2β1 in nonactivated conformation can induce focal adhesion kinase signaling An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.Two-dimensional kinetics regulation of alphaLbeta2-ICAM-1 interaction by conformational changes of the alphaL-inserted domain Integrin structure: new twists and turns in dynamic cell adhesion.Utilization of I-domain of LFA-1 to Target Drug and Marker Molecules to Leukocytes.Regulation of outside-in signaling and affinity by the beta2 I domain of integrin alphaLbeta2.AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes.Integrins, cations and ligands: making the connection.Importance of force linkage in mechanochemistry of adhesion receptors.The C-terminal αI domain linker as a critical structural element in the conformational activation of αI integrins Regulation of integrin affinity on cell surfaces Transmigration of neutrophils across inflamed endothelium is signaled through LFA-1 and Src family kinase.Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.The regulation of integrin function by divalent cations.The connection between metal ion affinity and ligand affinity in integrin I domains Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1.Impact of mutations on the allosteric conformational equilibrium.Activation of integrin beta-subunit I-like domains by one-turn C-terminal alpha-helix deletions Structure and mechanics of integrin-based cell adhesion.Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.Solution structure of the iron-sulfur cluster cochaperone HscB and its binding surface for the iron-sulfur assembly scaffold protein IscU

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NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding.

http://www.wikidata.org/entity/Q36967455

description

2000 nî lūn-bûn

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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2000年论文

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2000年论文

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name

NMR and mutagenesis evidence f ...... ated antigen 1 ligand binding.

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type

label

NMR and mutagenesis evidence f ...... ated antigen 1 ligand binding.

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prefLabel

NMR and mutagenesis evidence f ...... ated antigen 1 ligand binding.

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PNAS.97.10.5231

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Proceedings of the National Academy of Sciences of the United States of America

P1476

NMR and mutagenesis evidence f ...... ated antigen 1 ligand binding.

@en

P2093

Fesik SW

http://www.w3.org/2001/XMLSchema#string

Harris EA

http://www.w3.org/2001/XMLSchema#string

Huth JR

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Liang H

http://www.w3.org/2001/XMLSchema#string

Lupher ML Jr

http://www.w3.org/2001/XMLSchema#string

Mendoza R

http://www.w3.org/2001/XMLSchema#string

Olejniczak ET

http://www.w3.org/2001/XMLSchema#string

Staunton DE

http://www.w3.org/2001/XMLSchema#string

Wilson AE

http://www.w3.org/2001/XMLSchema#string

P2860

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand

Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

The von willebrand factor A3 domain does not contain a metal ion-dependent adhesion site motif

Crystal structure of the I domain from integrin alpha2beta1

P304

5231-5236

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scholarly article

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10.1073/PNAS.97.10.5231

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10

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97

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2000-05-01T00:00:00Z

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235617159

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10805782

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25811

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