Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.
about
Structure-function analysis of the Anopheles gambiae LRIM1/APL1C complex and its interaction with complement C3-like protein TEP1HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiencyTRIM5 is an innate immune sensor for the retrovirus capsid latticeTRIM5α and Species Tropism of HIV/SIVHIV type 1 Gag as a target for antiviral therapyAntibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)Coupling viruses to dynein and kinesin-1HIV restriction in quiescent CD4⁺ T cellsActive site remodeling switches HIV specificity of antiretroviral TRIMCypConformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral ActivityStructural insight into HIV-1 capsid recognition by rhesus TRIM5Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α SpecificityDiscovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid ComplexesThe tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid latticeTRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus MonkeysRhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfacesFates of retroviral core components during unrestricted and TRIM5-restricted infectionRhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral corePrimate TRIM5 proteins form hexagonal nets on HIV-1 capsids.Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.A rare null allele potentially encoding a dominant-negative TRIM5alpha protein in Baka pygmiesHexagonal assembly of a restricting TRIM5alpha proteinRecruitment and dynamics of proteasome association with rhTRIM5α cytoplasmic complexes during HIV-1 infection.Novel approaches to inhibiting HIV-1 replication.Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication.TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new speciesStabilized human TRIM5α protects human T cells from HIV-1 infection.Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins.Characterization of a core fragment of the rhesus monkey TRIM5α protein.The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain.TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro.Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction.Host and viral determinants for MxB restriction of HIV-1 infection.A novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screenHomology-based identification of capsid determinants that protect HIV1 from human TRIM5α restrictionThe role of BST2/tetherin in feline retrovirus infection
P2860
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P2860
Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Biochemical characterization o ...... ency virus type 1 replication.
@en
type
label
Biochemical characterization o ...... ency virus type 1 replication.
@en
prefLabel
Biochemical characterization o ...... ency virus type 1 replication.
@en
P2093
P2860
P356
P1433
P1476
Biochemical characterization o ...... iency virus type 1 replication
@en
P2093
Alak Kanti Kar
Charles R Langelier
Christopher Aiken
Debra M Eckert
Devin E Christensen
John C Olsen
Joseph G Sodroski
Steven L Alam
Virginie Sandrin
Wesley I Sundquist
P2860
P304
11682-11694
P356
10.1128/JVI.01562-08
P407
P577
2008-09-17T00:00:00Z