Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication. - Wikidata - wikimedia - TriplyDB

Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

http://www.wikidata.org/entity/Q36974763

about

Structure-function analysis of the Anopheles gambiae LRIM1/APL1C complex and its interaction with complement C3-like protein TEP1 HIV-1 capsid-cyclophilin interactions determine nuclear import pathway, integration targeting and replication efficiency TRIM5 is an innate immune sensor for the retrovirus capsid lattice TRIM5α and Species Tropism of HIV/SIV HIV type 1 Gag as a target for antiviral therapy Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)Coupling viruses to dynein and kinesin-1 HIV restriction in quiescent CD4⁺ T cells Active site remodeling switches HIV specificity of antiretroviral TRIMCyp Conformational Adaptation of Asian Macaque TRIMCyp Directs Lineage Specific Antiviral Activity Structural insight into HIV-1 capsid recognition by rhesus TRIM5 Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer.Structural studies of postentry restriction factors reveal antiparallel dimers that enable avid binding to the HIV-1 capsid lattice TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys Rhesus TRIM5α disrupts the HIV-1 capsid at the inter-hexamer interfaces Fates of retroviral core components during unrestricted and TRIM5-restricted infection Rhesus monkey TRIM5α SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral core Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids.Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α.Coarse-grained simulation reveals key features of HIV-1 capsid self-assembly.A rare null allele potentially encoding a dominant-negative TRIM5alpha protein in Baka pygmies Hexagonal assembly of a restricting TRIM5alpha protein Recruitment and dynamics of proteasome association with rhTRIM5α cytoplasmic complexes during HIV-1 infection.Novel approaches to inhibiting HIV-1 replication.Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication.TRIM5 suppresses cross-species transmission of a primate immunodeficiency virus and selects for emergence of resistant variants in the new species Stabilized human TRIM5α protects human T cells from HIV-1 infection.Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins.Characterization of a core fragment of the rhesus monkey TRIM5α protein.The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.Recognition of the HIV capsid by the TRIM5α restriction factor is mediated by a subset of pre-existing conformations of the TRIM5α SPRY domain.TRIM5alpha disrupts the structure of assembled HIV-1 capsid complexes in vitro.Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Multiple sites in the N-terminal half of simian immunodeficiency virus capsid protein contribute to evasion from rhesus monkey TRIM5α-mediated restriction.Host and viral determinants for MxB restriction of HIV-1 infection.A novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screen Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction The role of BST2/tetherin in feline retrovirus infection

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P2860

Biochemical characterization of a recombinant TRIM5alpha protein that restricts human immunodeficiency virus type 1 replication.

http://www.wikidata.org/entity/Q36974763

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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Biochemical characterization o ...... ency virus type 1 replication.

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Biochemical characterization o ...... ency virus type 1 replication.

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Biochemical characterization o ...... ency virus type 1 replication.

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Journal of Virology

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Biochemical characterization o ...... iency virus type 1 replication

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P2093

Alak Kanti Kar

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Charles R Langelier

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Christopher Aiken

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Debra M Eckert

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Devin E Christensen

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John C Olsen

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Joseph G Sodroski

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Steven L Alam

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Virginie Sandrin

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Wesley I Sundquist

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P2860

TRIM5alpha selectively binds a restriction-sensitive retroviral capsid

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex

BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta

Unique features of TRIM5alpha among closely related human TRIM family members

The role of LIP5 and CHMP5 in multivesicular body formation and HIV-1 budding in mammalian cells

Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection

Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5alpha restriction factor

Trim5alpha protein restricts both HIV-1 and murine leukemia virus

The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities

P304

11682-11694

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scholarly article

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10.1128/JVI.01562-08

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P433

23

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82

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Viswanathan Chandrasekaran

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2008-09-17T00:00:00Z

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23264763

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18799573

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2583683

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