Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice.
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Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet.Late-life rapamycin treatment reverses age-related heart dysfunction.Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency.Acute mTOR inhibition induces insulin resistance and alters substrate utilization in vivoNormalizing a hyperactive mTOR initiates muscle growth during obesityLiver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice.Insulin sensitivity in long-living Ames dwarf mice.The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice.Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction.Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression.Rapamycin Modulates Markers of Mitochondrial Biogenesis and Fatty Acid Oxidation in the Adipose Tissue of db/db Mice.Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside.Critical role for hypothalamic mTOR activity in energy balance.PRAS40: target or modulator of mTORC1 signalling and insulin action?Role of PRAS40 in Akt and mTOR signaling in health and disease.AICAR treatment for 14 days normalizes obesity-induced dysregulation of TORC1 signaling and translational capacity in fasted skeletal muscle.p21(WAF1/CIP1) Expression is Differentially Regulated by Metformin and Rapamycin.The effects of amino acids on glucose metabolism of isolated rat skeletal muscle are independent of insulin and the mTOR/S6K pathway.Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptakeThe PI3K/AKT pathway in obesity and type 2 diabetes
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P2860
Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Rapamycin does not improve ins ...... vity in muscles of ob/ob mice.
@en
type
label
Rapamycin does not improve ins ...... vity in muscles of ob/ob mice.
@en
prefLabel
Rapamycin does not improve ins ...... vity in muscles of ob/ob mice.
@en
P2093
P2860
P1476
Rapamycin does not improve ins ...... ivity in muscles of ob/ob mice
@en
P2093
Andrew M Miller
Charles B Phelps
E Zachary Berk
Thomas H Reynolds
P2860
P304
P356
10.1152/AJPREGU.90428.2008
P577
2008-09-03T00:00:00Z