Role of PRAS40 in Akt and mTOR signaling in health and disease.
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Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glanceArsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancerThe critical role of Akt in cardiovascular functionTargeting Pim kinases for cancer treatment: opportunities and challengesPRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathwaysThe Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond.Akt inhibitor MK2206 prevents influenza pH1N1 virus infection in vitro.Low Molecular Weight Fraction of Commercial Human Serum Albumin Induces Morphologic and Transcriptional Changes of Bone Marrow-Derived Mesenchymal Stem CellsMutation of mouse Samd4 causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling.Mechanistic target of rapamycin complex 2 protects the heart from ischemic damageNuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway.AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axisPreclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts.Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic SensitivityPRAS40 deregulates apoptosis in Ewing sarcoma family tumors by enhancing the insulin receptor/Akt and mTOR signaling pathwaysPathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1Transcriptomic and phospho-proteomic analyzes of erythroblasts expanded in vitro from normal donors and from patients with polycythemia vera.miR-564 acts as a dual inhibitor of PI3K and MAPK signaling networks and inhibits proliferation and invasion in breast cancer.Effect of Sfrp5 on cytokine release and insulin action in primary human adipocytes and skeletal muscle cells.Proteomic analyses of brain tumor cell lines amidst the unfolded protein responseGermline BRCA1 mutation reprograms breast epithelial cell metabolism towards mitochondrial-dependent biosynthesis: evidence for metformin-based "starvation" strategies in BRCA1 carriers.Buparlisib, a PI3K inhibitor, demonstrates acceptable tolerability and preliminary activity in a phase I trial of patients with advanced leukemias.mTOR function and therapeutic targeting in breast cancer.Targeting phosphatidylinositol 3-kinase signaling in acute myelogenous leukemia.Targeting the mTOR signaling network for Alzheimer's disease therapy.mTOR in Brain Physiology and Pathologies.Akt Activation Mediates Acquired Resistance to Fibroblast Growth Factor Receptor Inhibitor BGJ398.PF573,228 inhibits vascular tumor cell growth, migration as well as angiogenesis, induces apoptosis and abrogates PRAS40 and S6RP phosphorylation.Pasteurella multocida toxin- induced osteoclastogenesis requires mTOR activation.Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma.Targeting protein kinase-b3 (akt3) signaling in melanoma.Considerations on mTOR regulation at serine 2448: implications for muscle metabolism studies.The role of TGFBI (βig-H3) in gastrointestinal tract tumorigenesis.Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer.PRAS40 promotes NF-κB transcriptional activity through association with p65.Alpha Lipoic Acid Modulated High Glucose-Induced Rat Mesangial Cell Dysfunction via mTOR/p70S6K/4E-BP1 Pathway.PRAS40 signaling in tumor.TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies.mTOR/PRAS40 interaction: hypertrophy or proliferation.Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway.
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Role of PRAS40 in Akt and mTOR signaling in health and disease.
description
article científic
@ca
article scientifique
@fr
articol științific
@ro
articolo scientifico
@it
artigo científico
@gl
artigo científico
@pt
artigo científico
@pt-br
artikel ilmiah
@id
artikull shkencor
@sq
artículo científico
@es
name
Role of PRAS40 in Akt and mTOR signaling in health and disease.
@en
Role of PRAS40 in Akt and mTOR signaling in health and disease.
@nl
type
label
Role of PRAS40 in Akt and mTOR signaling in health and disease.
@en
Role of PRAS40 in Akt and mTOR signaling in health and disease.
@nl
prefLabel
Role of PRAS40 in Akt and mTOR signaling in health and disease.
@en
Role of PRAS40 in Akt and mTOR signaling in health and disease.
@nl
P2860
P1476
Role of PRAS40 in Akt and mTOR signaling in health and disease
@en
P2093
Claudia Wiza
P2860
P304
P356
10.1152/AJPENDO.00660.2011
P577
2012-02-21T00:00:00Z