PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
about
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1Structural analysis and functional implications of the negative mTORC1 regulator REDD1Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acidsSREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthNutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagyDEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survivalThe Rag GTPases bind raptor and mediate amino acid signaling to mTORC1PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complexAMPK phosphorylation of raptor mediates a metabolic checkpointNaturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismRegulation of TOR by small GTPasesUpdates of mTOR inhibitorsResveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORSpatial regulation of the mTORC1 system in amino acids sensing pathwayOsmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal Kinase (JNK)-mediated Raptor protein phosphorylationThe mTOR signalling pathway in human cancerAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyMammalian target of rapamycin (mTOR): conducting the cellular signaling symphonyTherapeutic Implications of Targeting AKT Signaling in MelanomamTOR: from growth signal integration to cancer, diabetes and ageingSkeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucinemTOR signaling in growth control and diseaseThe proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1The TSC1-TSC2 complex: a molecular switchboard controlling cell growthRegulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylationAKT/PKB signaling: navigating downstreammTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceAberrant hyperactivation of akt and Mammalian target of rapamycin complex 1 signaling in sporadic chordomasHypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttlingThe role of amino acid-induced mammalian target of rapamycin complex 1(mTORC1) signaling in insulin resistanceConserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signalingAutophagy signal transduction by ATG proteins: from hierarchies to networksIL-15-PI3K-AKT-mTOR: A Critical Pathway in the Life Journey of Natural Killer CellsThe neurology of mTORWhat a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathwayTherapeutic targeting of autophagy: potential and concerns in treating cardiovascular diseaseCutting through the complexities of mTOR for the treatment of strokePI3K-AKT-mTOR-signaling and beyond: the complex network in gastroenteropancreatic neuroendocrine neoplasmsmTOR-dependent cell survival mechanisms
P2860
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P2860
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
description
2007 nî lūn-bûn
@nan
2007 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մարտին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@ast
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en-gb
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@nl
type
label
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@ast
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en-gb
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@nl
prefLabel
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@ast
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en-gb
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@nl
P2093
P3181
P1433
P1476
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
@en
P2093
Carson C Thoreen
Eric Spooner
Robert A Lindquist
Seong A Kang
Steven A Carr
Timothy R Peterson
Yasemin Sancak
P304
P3181
P356
10.1016/J.MOLCEL.2007.03.003
P407
P577
2007-03-01T00:00:00Z