Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
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IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like protein expressionDecitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivoc-FLIP, a master anti-apoptotic regulatorERK/MAPK is essential for endogenous neuroprotection in SCN2.2 cellsSorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.On-bead screens sample narrower affinity ranges of protein-ligand interactions compared to equivalent solution assays.Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivoA serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.Small-molecule inhibitors of p21 as novel therapeutics for chemotherapy-resistant kidney cancer.Sphingosine-1-phosphate phosphohydrolase-1 regulates ER stress-induced autophagyThe novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphomaInhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression.Targeting the Anti-Apoptotic Protein c-FLIP for Cancer Therapy.Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancerSuppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic miceDown-regulation of cellular FLICE-inhibitory protein (Long Form) contributes to apoptosis induced by Hsp90 inhibition in human lung cancer cellsSynergistic combinations of signaling pathway inhibitors: mechanisms for improved cancer therapy.BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.Inhibition of MCL-1 enhances lapatinib toxicity and overcomes lapatinib resistance via BAK-dependent autophagy.Cancer-selective apoptotic effects of extracellular and intracellular Par-4.Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.Influences of the circadian clock on neuronal susceptibility to excitotoxicity.Nanoformulated Mutant SurR9-C84A: a Possible Key for Alzheimer's and its Associated Inflammation.Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells.Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK).Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.17-allylamino-17-demethoxygeldanamycin and MEK1/2 inhibitors kill GI tumor cells via Ca2+-dependent suppression of GRP78/BiP and induction of ceramide and reactive oxygen speciesGlutamate excitotoxicity activates the MAPK/ERK signaling pathway and induces the survival of rat hippocampal neurons in vivo.
P2860
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P2860
Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Mitogen-activated protein kina ...... levels and activation of CD95.
@en
type
label
Mitogen-activated protein kina ...... levels and activation of CD95.
@en
prefLabel
Mitogen-activated protein kina ...... levels and activation of CD95.
@en
P2093
P2860
P1476
Mitogen-activated protein kina ...... levels and activation of CD95.
@en
P2093
Adly Yacoub
Clint Mitchell
Hossein Hamed
Margaret A Park
Michael P Hagan
Mohamed Rahmani
Paul B Fisher
Steven Grant
P2860
P304
P356
10.1158/1535-7163.MCT-08-0400
P577
2008-09-01T00:00:00Z