Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.
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PUMA, a potent killer with or without p53Bile acids: regulation of apoptosis by ursodeoxycholic acidCells expressing the C/EBPbeta isoform, LIP, engulf their neighborsDeoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells.Cyclic AMP stimulates Mrp2 translocation by activating p38{alpha} MAPK in hepatic cells.Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.INTRACELLULAR SIGNALING BY BILE ACIDS.Endocrine functions of bile acids.Bile acid signaling and liver regeneration.Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3.The bile acid membrane receptor TGR5: a valuable metabolic target.Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice.The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts.Death by association: BH3 domain-only proteins and liver injury.Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis.Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.JunD protects the liver from ischemia/reperfusion injury by dampening AP-1 transcriptional activation.Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathwayVorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.Mitogen-activated protein kinase kinase 1/2 inhibitors and 17-allylamino-17-demethoxygeldanamycin synergize to kill human gastrointestinal tumor cells in vitro via suppression of c-FLIP-s levels and activation of CD95.Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance.Intra-amygdala injections of CREB antisense impair inhibitory avoidance memory: role of norepinephrine and acetylcholine.APE1-mediated DNA damage repair provides survival advantage for esophageal adenocarcinoma cells in response to acidic bile salts.C-Jun N-terminal kinase 2 promotes graft injury via the mitochondrial permeability transition after mouse liver transplantation.Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activationTransforming growth factor-beta1 causes pulmonary microvascular endothelial cell apoptosis via ALK5.Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet.HIV protease inhibitor lopinavir-induced TNF-alpha and IL-6 expression is coupled to the unfolded protein response and ERK signaling pathways in macrophages.BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration.Effects of ethanol on insulin-like growth factor-I system in primary cultured rat hepatocytes: implications of JNK1/2 and alcoholdehydrogenase.c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.Bile acids: short and long term effects in the intestine.Acidified bile acids enhance tumor progression and telomerase activity of gastric cancer in mice dependent on c-Myc expression.Bacterial bile salt hydrolase: an intestinal microbiome target for enhanced animal health.Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
P2860
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P2860
Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@ast
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@en
type
label
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@ast
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@en
prefLabel
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@ast
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@en
P2093
P2860
P1476
Bile acid regulation of C/EBPb ...... totic response of hepatocytes.
@en
P2093
Donna Gilfor
George Amorino
John F Engelhardt
Jong Sung Park
Kristoffer Valerie
Liang Qiao
Linda Sealy
Philip B Hylemon
Seema Gupta
Song Iy Han
P2860
P304
P356
10.1128/MCB.23.9.3052-3066.2003
P407
P50
P577
2003-05-01T00:00:00Z