Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease.
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COT phosphorylates prolyl-isomerase Pin1 to promote tumorigenesis in breast cancerThe yeast Ess1 prolyl isomerase controls Swi6 and Whi5 nuclear localization.KSHV reactivation and novel implications of protein isomerization on lytic switch controlThe prolyl isomerase Pin1 targets stem-loop binding protein (SLBP) to dissociate the SLBP-histone mRNA complex linking histone mRNA decay with SLBP ubiquitinationPin1 promotes transforming growth factor-beta-induced migration and invasion.A common biological mechanism in cancer and Alzheimer's disease?Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcriptionPhysiological regulation of Akt activity and stability.The Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle.Prolyl isomerase pin1 protects mice from endotoxin shock.Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study.Prolyl isomerase Pin1 regulates transcription factor LSF (TFCP2) by facilitating dephosphorylation at two serine-proline motifs.Brown Algae Polyphenol, a Prolyl Isomerase Pin1 Inhibitor, Prevents Obesity by Inhibiting the Differentiation of Stem Cells into Adipocytes.Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.Mycobacterium tuberculosis cyclophilin A uses novel signal sequence for secretion and mimics eukaryotic cyclophilins for interaction with host protein repertoirePin1 promotes degradation of Smad proteins and their interaction with phosphorylated tau in Alzheimer's disease.A high-throughput screen for inhibitors of the prolyl isomerase, Pin1, identifies a seaweed polyphenol that reduces adipose cell differentiation.Endoplasmic reticulum stress or mutation of an EF-hand Ca(2+)-binding domain directs the FKBP65 rotamase to an ERAD-based proteolysisMixed-lineage kinase 3 phosphorylates prolyl-isomerase Pin1 to regulate its nuclear translocation and cellular functionRole of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent modelComplete thermodynamic and kinetic characterization of the isomer-specific interaction between Pin1-WW domain and the amyloid precursor protein cytoplasmic tail phosphorylated at Thr668.The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury.Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation.Associations between cancer and Alzheimer's disease in a U.S. Medicare population.Bladder cancer SNP panel predicts susceptibility and survivalPin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process.ShaPINg Cell Fate Upon DNA Damage: Role of Pin1 Isomerase in DNA Damage-Induced Cell Death and Repair.Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis.Effect of Pin1 or microtubule binding on dephosphorylation of FTDP-17 mutant TauThe alphabet of intrinsic disorder: I. Act like a Pro: On the abundance and roles of proline residues in intrinsically disordered proteins.The role of Pin1 in the development and treatment of cancer.The cellular peptidyl-prolyl cis/trans isomerase Pin1 regulates reactivation of Kaposi's sarcoma-associated herpesvirus from latencyDecursin exerts anti-cancer activity in MDA-MB-231 breast cancer cells via inhibition of the Pin1 activity and enhancement of the Pin1/p53 association.Overexpression of peptidyl-prolyl isomerase Pin1 attenuates hepatocytes apoptosis and secondary necrosis following carbon tetrachloride-induced acute liver injury in mice.Increased expression of PIN1 gene in papillary thyroid carcinoma.Alterations in brain antioxidant enzymes and redox proteomic identification of oxidized brain proteins induced by the anti-cancer drug adriamycin: implications for oxidative stress-mediated chemobrain.Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activityNon-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding.Initiation of prolyl cis-trans isomerisation in the CDR-H3 loop of an antibody in response to antigen binding.Pin1-mediated prolyl isomerization of Runx1 affects PU.1 expression in pre-monocytes.
P2860
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P2860
Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Prolyl isomerase, Pin1: new fi ...... sthma and Alzheimer's disease.
@en
type
label
Prolyl isomerase, Pin1: new fi ...... sthma and Alzheimer's disease.
@en
prefLabel
Prolyl isomerase, Pin1: new fi ...... sthma and Alzheimer's disease.
@en
P2093
P1476
Prolyl isomerase, Pin1: new fi ...... sthma and Alzheimer's disease.
@en
P2093
P2888
P304
P356
10.1007/S00018-007-7270-0
P577
2008-02-01T00:00:00Z