Activation and dynamic network of the M2 muscarinic receptor.
about
Activation and allosteric modulation of a muscarinic acetylcholine receptorPrinciples and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicsExploring the role of receptor flexibility in structure-based drug discoveryGaussian Accelerated Molecular Dynamics: Unconstrained Enhanced Sampling and Free Energy CalculationComputational studies of the binding profile of phosphoinositide PtdIns (3,4,5) P₃ with the pleckstrin homology domain of an oomycete cellulose synthaseTheoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation.Emerging Computational Methods for the Rational Discovery of Allosteric Drugs.Allosteric regulation of the Hsp90 dynamics and stability by client recruiter cochaperones: protein structure network modelingComputational modeling of allosteric regulation in the hsp90 chaperones: a statistical ensemble analysis of protein structure networks and allosteric communications.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Detection of Side Chain Rearrangements Mediating the Motions of Transmembrane Helices in Molecular Dynamics Simulations of G Protein-Coupled Receptors.Structure-based simulations reveal concerted dynamics of GPCR activationMapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptorAccelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor.Improved Reweighting of Accelerated Molecular Dynamics Simulations for Free Energy Calculation.Differences in allosteric communication pipelines in the inactive and active states of a GPCR.Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors.Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists.Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor.Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism.Accelerated molecular dynamics simulations of protein folding.Differential Regulation of 6- and 7-Transmembrane Helix Variants of μ-Opioid Receptor in Response to Morphine StimulationLong-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication PathwaysStructural and Functional Effect of an Oscillating Electric Field on the Dopamine-D3 Receptor: A Molecular Dynamics Simulation Study.Molecular determinants for the thermodynamic and functional divergence of uniporter GLUT1 and proton symporter XylE.Insights into the Structural Dynamics of Nucleocytoplasmic Transport of tRNA by Exportin-t.Computational approaches to detect allosteric pathways in transmembrane molecular machines.Unconstrained Enhanced Sampling for Free Energy Calculations of Biomolecules: A ReviewMechanistic Studies on the Stereoselectivity of the Serotonin 5-HT1A Receptor.Toward high-resolution computational design of the structure and function of helical membrane proteinsAccelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor.Fighting Cancer with Transition Metal Complexes: From Naked DNA to Protein and Chromatin Targeting Strategies.Graded activation and free energy landscapes of a muscarinic G-protein-coupled receptor.Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.Weighted Implementation of Suboptimal Paths (WISP): An Optimized Algorithm and Tool for Dynamical Network Analysis.Free energy landscape of G-protein coupled receptors, explored by accelerated molecular dynamicsGeneral trends of dihedral conformational transitions in a globular protein.Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors.G-protein coupled receptors: advances in simulation and drug discovery.
P2860
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P2860
Activation and dynamic network of the M2 muscarinic receptor.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Activation and dynamic network of the M2 muscarinic receptor.
@en
type
label
Activation and dynamic network of the M2 muscarinic receptor.
@en
prefLabel
Activation and dynamic network of the M2 muscarinic receptor.
@en
P2093
P2860
P356
P1476
Activation and dynamic network of the M2 muscarinic receptor.
@en
P2093
Paul M Gasper
Sara E Nichols
Vincent T Metzger
Yinglong Miao
P2860
P304
10982-10987
P356
10.1073/PNAS.1309755110
P407
P577
2013-06-18T00:00:00Z