Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.
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Novel small molecule Raf kinase inhibitors for targeted cancer therapeuticsMetabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficaciesSpirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cellsSTATs in cancer inflammation and immunity: a leading role for STAT3Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma.Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapySorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy.Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts.Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effectsSorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2.Interleukin-6 in bone metastasis and cancer progression.Schedule-dependent antitumor effects of 5-fluorouracil combined with sorafenib in hepatocellular carcinomaSorafenib inhibits growth and metastasis of hepatocellular carcinoma by blocking STAT3Sorafenib exerts anti-glioma activity in vitro and in vivo.A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3.Repurposing FDA-approved drugs as therapeutics to treat Rift Valley fever virus infection.Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition.Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cellsBortezomib induces apoptosis and growth suppression in human medulloblastoma cells, associated with inhibition of AKT and NF-ĸB signaling, and synergizes with an ERK inhibitorThe Raf Kinase Inhibitor Sorafenib Inhibits JAK-STAT Signal Transduction in Human Immune CellsMCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.Sorafenib and its derivative SC-49 sensitize hepatocellular carcinoma cells to CS-1008, a humanized anti-TNFRSF10B (DR5) antibody.Ovatodiolide Targets β -Catenin Signaling in Suppressing Tumorigenesis and Overcoming Drug Resistance in Renal Cell Carcinoma.PP2A inhibition with LB100 enhances cisplatin cytotoxicity and overcomes cisplatin resistance in medulloblastoma cells.Human cytomegalovirus IE1 protein disrupts interleukin-6 signaling by sequestering STAT3 in the nucleus.Initial testing (stage 1) of the multi-targeted kinase inhibitor sorafenib by the pediatric preclinical testing programPeripheral medulloepithelioma: a rare tumor with a potential target therapy.Inflammation: what role in pediatric cancer?Inhibition of Autophagy by Chloroquine Enhances the Antitumor Efficacy of Sorafenib in Glioblastoma.The PI3K inhibitor GDC-0941 displays promising in vitro and in vivo efficacy for targeted medulloblastoma therapyInhibition of cellular STAT3 synergizes with the cytomegalovirus kinase inhibitor maribavir to disrupt infection.RASSF1A and the BH3-only mimetic ABT-737 promote apoptosis in pediatric medulloblastoma cell lines.Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.The multikinase inhibitor sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE₂ in murine macrophages.Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell lineSunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways.Comprehensive Analysis of miRNome Alterations in Response to Sorafenib Treatment in Colorectal Cancer Cells.The anti-neoplastic activity of Vandetanib against high-risk medulloblastoma variants is profoundly enhanced by additional PI3K inhibitionEnhancing CHK1 inhibitor lethality in glioblastoma.
P2860
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P2860
Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Sorafenib inhibits signal tran ...... apoptosis of medulloblastomas.
@en
type
label
Sorafenib inhibits signal tran ...... apoptosis of medulloblastomas.
@en
prefLabel
Sorafenib inhibits signal tran ...... apoptosis of medulloblastomas.
@en
P2093
P2860
P1476
Sorafenib inhibits signal tran ...... apoptosis of medulloblastomas.
@en
P2093
Claudia M Kowolik
Janni Mirosevich
Mark Kirschbaum
Michael Hedvat
Mike Y Chen
Nilesh Mepani
Ralf Buettner
Richard Jove
P2860
P304
P356
10.1158/1535-7163.MCT-08-0138
P577
2008-11-01T00:00:00Z