Characterization of cancer-associated missense mutations in MDM2.

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Characterization of cancer-associated missense mutations in MDM2.

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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Characterization of cancer-associated missense mutations in MDM2.

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Characterization of cancer-associated missense mutations in MDM2.

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Characterization of cancer-associated missense mutations in MDM2.

@en

P1476

Characterization of cancer-associated missense mutations in MDM2.

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P2093

Gopalakrishnan Ramakrishnan

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Krishna M Chauhan

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Luis A Martinez

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Madhusudhan Kollareddy

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P2860

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

An essential function of the extreme C-terminus of MDM2 can be provided by MDMX

Recognition of the polyubiquitin proteolytic signal

Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

Molecular analysis and chromosomal mapping of amplified genes isolated from a transformed mouse 3T3 cell line

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage

P304

e1125986

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P31

scholarly article

P356

10.1080/23723556.2015.1125986

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P433

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P478

http://www.w3.org/2001/XMLSchema#string

P577

2015-12-10T00:00:00Z

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P5875

286455973

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P698

27308622

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P932

4905418

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