Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps.

Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps.

Item
http://www.wikidata.org/entity/Q37001433
Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsIdentification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for TauopathiesStructural determinants of Tau aggregation inhibitor potencyAffinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.Hirano bodies differentially modulate cell death induced by tau and the amyloid precursor protein intracellular domain.Pseudophosphorylation of tau protein directly modulates its aggregation kinetics.The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.Tau isoform composition influences rate and extent of filament formationModulation and detection of tau aggregation with small-molecule ligandsStructure-activity relationship of cyanine tau aggregation inhibitors.Cellular factors modulating the mechanism of tau protein aggregation.Interactions between Microtubule-Associated Protein Tau (MAPT) and Small Molecules.Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies.Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention.Formation and propagation of tau oligomeric seeds.Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.
P2860

Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps.

Item
http://www.wikidata.org/entity/Q37001433
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 18 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@en
Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@nl
type
label
Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@en
Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@nl
prefLabel
Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@en
Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@nl
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P1476
P2093
P2860
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P356
P407
P433
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P577
P5875
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Pathogenic missense MAPT mutat ...... ucleation and extension steps.
@en
P2093
P2860
P304
P31
P356
10.1111/J.1471-4159.2008.05692.X
P407
P433
P478
P577
P5875
P698
P932