Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.
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Astrocytes: the missing link in neurologic disease?Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 CellsRetinal very long-chain PUFAs: new insights from studies on ELOVL4 proteinVery long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy.Pathomechanisms underlying X-adrenoleukodystrophy: a three-hit hypothesis.Peroxisomal dysfunction in inflammatory childhood white matter disorders: an unexpected contributor to neuropathologyHistone deacetylase inhibitor upregulates peroxisomal fatty acid oxidation and inhibits apoptotic cell death in abcd1-deficient glial cells.Loss of AMP-activated protein kinase induces mitochondrial dysfunction and proinflammatory response in unstimulated Abcd1-knockout mice mixed glial cells.HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.ABCD1 deletion-induced mitochondrial dysfunction is corrected by SAHA: implication for adrenoleukodystrophy.Functional genomic analysis unravels a metabolic-inflammatory interplay in adrenoleukodystrophyCaffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes.Peroxisomes, myelination, and axonal integrity in the CNS.The PPAR-γ agonist pioglitazone protects cortical neurons from inflammatory mediators via improvement in peroxisomal function.Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.A genome-wide DNA methylation analysis in peripheral blood from patients identifies risk loci associated with Graves' orbitopathy.A zebrafish model of X-linked adrenoleukodystrophy recapitulates key disease features and demonstrates a developmental requirement for abcd1 in oligodendrocyte patterning and myelination.Metformin-induced mitochondrial function and ABCD2 up-regulation in X-linked adrenoleukodystrophy involves AMP-activated protein kinase.MicroRNA Profiling Identifies miR-196a as Differentially Expressed in Childhood Adrenoleukodystrophy and Adult Adrenomyeloneuropathy.
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P2860
Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 21 August 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
@en
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
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type
label
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
@en
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
@nl
prefLabel
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
@en
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
@nl
P2093
P2860
P921
P1476
Silencing of Abcd1 and Abcd2 g ...... on for X-adrenoleukodystrophy.
@en
P2093
Inderjit Singh
Jaspreet Singh
Mushfiquddin Khan
P2860
P304
P356
10.1194/JLR.M800321-JLR200
P577
2008-08-21T00:00:00Z