Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential.

Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential.

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http://www.wikidata.org/entity/Q37021156

Q37021156

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Retroviral vectors and transposons for stable gene therapy: advances, current challenges and perspectives Uncovering and dissecting the genotoxicity of self-inactivating lentiviral vectors in vivo Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.β-globin gene transfer to human bone marrow for sickle cell disease.Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors.A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells.Scavenger receptors and their potential as therapeutic targets in the treatment of cardiovascular disease Thymidine kinase suicide gene-mediated ganciclovir ablation of autologous gene-modified rhesus hematopoiesis.Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity Potentially therapeutic levels of anti-sickling globin gene expression following lentivirus-mediated gene transfer in sickle cell disease bone marrow CD34+ cells.The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells.Strategies to insulate lentiviral vector-expressed transgenes Genetic treatment of a molecular disorder: gene therapy approaches to sickle cell disease.Does retroviral insertional mutagenesis play a role in the generation of induced pluripotent stem cells?The genotoxic potential of retroviral vectors is strongly modulated by vector design and integration site selection in a mouse model of HSC gene therapy Preventing and exploiting the oncogenic potential of integrating gene vectors.Development of gene therapy: potential in severe combined immunodeficiency due to adenosine deaminase deficiency.Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector.Characterization of a third generation lentiviral vector pseudotyped with Nipah virus envelope proteins for endothelial cell transduction.Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Gene therapy for β-thalassaemia: the continuing challenge.The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors Development of gene therapy for thalassemia.Biosafety features of lentiviral vectors A self-deletion lentiviral vector to reduce the risk of replication-competent virus formation.Evidence for the in vivo safety of insulated foamy viral vectors Insulated Foamy Viral Vectors.Development of murine leukemia virus-based retroviral vectors with a minimum possibility of cis-activation.CTF/NF1 transcription factors act as potent genetic insulators for integrating gene transfer vectors.A tale of two SCIDs.Hematopoietic Stem Cell Gene Therapy: Progress and Lessons Learned.Design and Potential of Non-Integrating Lentiviral Vectors.Factor VIII delivered by haematopoietic stem cell-derived B cells corrects the phenotype of haemophilia A mice.Gene Therapy for Hemoglobinopathies

P2860

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P2860

Combinatorial incorporation of enhancer-blocking components of the chicken beta-globin 5'HS4 and human T-cell receptor alpha/delta BEAD-1 insulators in self-inactivating retroviral vectors reduces their genotoxic potential.

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http://www.wikidata.org/entity/Q37021156

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 11 September 2008

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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