Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance.
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The C-terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζCrystal structure of human REV7 in complex with a human REV3 fragment and structural implication of the interaction between DNA polymerase zeta and REV1Eukaryotic translesion polymerases and their roles and regulation in DNA damage toleranceStructure of the Human Rev1–DNA–dNTP Ternary ComplexUnconventional Ubiquitin Recognition by the Ubiquitin-Binding Motif within the Y Family DNA Polymerases ι and Rev1Structure and Functional Analysis of the BRCT Domain of Translesion Synthesis DNA Polymerase Rev1NMR Structure and Dynamics of the C-Terminal Domain from Human Rev1 and Its Complex with Rev1 Interacting Region of DNA Polymerase ηMultifaceted Recognition of Vertebrate Rev1 by Translesion Polymerases ζ and κThe mechanisms of UV mutagenesis.The structural basis of XRCC1-mediated DNA repairDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeThe vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled siteThe DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Proteasomal regulation of the mutagenic translesion DNA polymerase, Saccharomyces cerevisiae Rev1.The non-canonical protein binding site at the monomer-monomer interface of yeast proliferating cell nuclear antigen (PCNA) regulates the Rev1-PCNA interaction and Polζ/Rev1-dependent translesion DNA synthesis.The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites.Y-family DNA polymerases and their role in tolerance of cellular DNA damage.Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Translesion DNA synthesis and mutagenesis in eukaryotesREV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1.XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repairInsights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain.
P2860
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P2860
Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 July 2008
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vedecký článok
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vetenskaplig artikel
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Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
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Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
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type
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Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
@en
Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
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prefLabel
Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
@en
Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
@nl
P2093
P2860
P1433
P1476
Novel conserved motifs in Rev1 ...... utagenic DNA damage tolerance.
@en
P2093
Graham C Walker
Lauren S Waters
Sanjay D'Souza
P2860
P304
P356
10.1016/J.DNAREP.2008.05.009
P577
2008-07-07T00:00:00Z