Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.
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Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitroSterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivoProteasomal degradation of ubiquitinated Insig proteins is determined by serine residues flanking ubiquitinated lysinesMevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbitsUnsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination stepPut your heart into the joint benefits of statins!A novel therapeutic effect of statins on nephrogenic diabetes insipidusIntracellular oxygen determined by respiration regulates localization of Ras and prenylated proteins.Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liverInsig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienolsThe gamma subunit of transducin is farnesylatedThe reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reactionThe Arabidopsis dwf7/ste1 mutant is defective in the delta7 sterol C-5 desaturation step leading to brassinosteroid biosynthesisSchoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsSevere facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatinVolatile emission in bracken fern is induced by jasmonates but not by Spodoptera littoralis or Strongylogaster multifasciata herbivoryImportance of the anticodon sequence in the aminoacylation of tRNAs by methionyl-tRNA synthetase and by valyl-tRNA synthetase in an Archaebacterium.Measurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsThe nonmevalonate pathway supports both monoterpene and sesquiterpene formation in snapdragon flowersComparison of effects of different statins on growth and steroidogenesis of rat ovarian theca-interstitial cells.Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis.Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductaseSuppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseTherapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2.Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasisSimvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape.Simvastatin prevents and reverses depigmentation in a mouse model of vitiligoThe prenyltransferase UBIAD1 is the target of geranylgeraniol in degradation of HMG CoA reductaseTomato hydroxymethylglutaryl-CoA reductase is required early in fruit development but not during ripening.Scap is required for sterol synthesis and crypt growth in intestinal mucosa.Novel effects of simvastatin on uterine fibroid tumors: in vitro and patient-derived xenograft mouse model study.Rosuvastatin reduces neointima formation in a rat model of balloon injury.Gene replacement in Halobacterium halobium and expression of bacteriorhodopsin mutants.A short-term statin treatment changes the contractile properties of fast-twitch skeletal musclesAnalysis of nuclear lamin isoprenylation in Xenopus oocytes: isoprenylation of lamin B3 precedes its uptake into the nucleus.In vivo requirement of protein prenylation for maintenance of retinal cytoarchitecture and photoreceptor structure.Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.The CaaX motif is required for isoprenylation, carboxyl methylation, and nuclear membrane association of lamin B2.
P2860
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P2860
Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.
description
1980 nî lūn-bûn
@nan
1980年の論文
@ja
1980年学术文章
@wuu
1980年学术文章
@zh-cn
1980年学术文章
@zh-hans
1980年学术文章
@zh-my
1980年学术文章
@zh-sg
1980年學術文章
@yue
1980年學術文章
@zh
1980年學術文章
@zh-hant
name
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@en
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@nl
type
label
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@en
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@nl
prefLabel
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@en
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@nl
P2093
P2860
P356
P1476
Feedback regulation of 3-hydro ...... ve inhibitor of the reductase.
@en
P2093
P2860
P304
P356
10.1172/JCI109938
P407
P577
1980-11-01T00:00:00Z