STAT3 as a target for inducing apoptosis in solid and hematological tumors
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Apoptosis induced by knockdown of uPAR and MMP-9 is mediated by inactivation of EGFR/STAT3 signaling in medulloblastomaSTAT1 activation regulates proliferation and differentiation of renal progenitorsGrowth arrest and DNA damage 45G down-regulation contributes to Janus kinase/signal transducer and activator of transcription 3 activation and cellular senescence evasion in hepatocellular carcinomaLow level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell modelSpirooxindole derivative SOID-8 induces apoptosis associated with inhibition of JAK2/STAT3 signaling in melanoma cellsScoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activityIn vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin BHighly pathogenic avian influenza H5N1 virus delays apoptotic responses via activation of STAT3.Phase I study of OPB-51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies.Genetic polymorphisms of STAT3 correlated with prognosis in diffuse large B-cell lymphoma patients treated with rituximab.The neuroleptic drug pimozide inhibits stem-like cell maintenance and tumorigenicity in hepatocellular carcinoma.5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapyA cell-permeable Stat3 SH2 domain mimetic inhibits Stat3 activation and induces antitumor cell effects in vitro.Non-cell-autonomous stimulation of stem cell proliferation following ablation of Tcf3.Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration.Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibitionA STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB.Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3).STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma.Solanum nigrum Unripe fruit fraction attenuates Adriamycin resistance by down-regulating multi-drug resistance protein (Mdr)-1 through Jak-STAT pathway.Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma.Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors.Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells.Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells.TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivoA STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.Benzoxathiol derivative BOT-4-one suppresses L540 lymphoma cell survival and proliferation via inhibition of JAK3/STAT3 signaling.STAT3 Knockdown in B16 Melanoma by siRNA Lipopolyplexes Induces Bystander Immune Response In Vitro and In VivoChemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.Drug transporter-independent liver cancer cell killing by a marine steroid methyl spongoate via apoptosis induction.A novel curcumin analog (H-4073) enhances the therapeutic efficacy of cisplatin treatment in head and neck cancerDesign and in vitro evaluation of layer by layer siRNA nanovectors targeting breast tumor initiating cellsScoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells.A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processesNF-κB and STAT3 - key players in liver inflammation and cancerAberrantly expressed Fra-1 by IL-6/STAT3 transactivation promotes colorectal cancer aggressiveness through epithelial-mesenchymal transition.Therapeutic potential of AZD1480 for the treatment of human glioblastoma
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STAT3 as a target for inducing apoptosis in solid and hematological tumors
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on February 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
STAT3 as a target for inducing apoptosis in solid and hematological tumors
@en
STAT3 as a target for inducing apoptosis in solid and hematological tumors.
@nl
type
label
STAT3 as a target for inducing apoptosis in solid and hematological tumors
@en
STAT3 as a target for inducing apoptosis in solid and hematological tumors.
@nl
prefLabel
STAT3 as a target for inducing apoptosis in solid and hematological tumors
@en
STAT3 as a target for inducing apoptosis in solid and hematological tumors.
@nl
P2860
P356
P1433
P1476
STAT3 as a target for inducing apoptosis in solid and hematological tumors
@en
P2093
James Turkson
Khandaker Al Zaid Siddiquee
P2860
P2888
P304
P356
10.1038/CR.2008.18
P577
2008-02-01T00:00:00Z
P5875
P6179
1008695398