Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo. - Wikidata - wikimedia - TriplyDB

Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.

Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.

http://www.wikidata.org/entity/Q37033601

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Emerging role of cell polarity proteins in breast cancer progression and metastasis Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ Phenotypical analysis of atypical PKCs in vivo function display a compensatory system at mouse embryonic day 7.5 Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications.Plexin-A4-semaphorin 3A signaling is required for Toll-like receptor- and sepsis-induced cytokine storm HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth PRKC-ζ Expression Promotes the Aggressive Phenotype of Human Prostate Cancer Cells and Is a Novel Target for Therapeutic Intervention.Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism Cancer-associated protein kinase C mutations reveal kinase's role as tumor suppressor Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells.Expression of polarity genes in human cancer.aPKC phosphorylation of HDAC6 results in increased deacetylation activity Role of ellagic acid in regulation of apoptosis by modulating novel and atypical PKC in lymphoma bearing mice Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ Down-regulation of PKCζ in renal cell carcinoma and its clinicopathological implications.PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65.The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.Functional comparison of protein domains within aPKCs involved in nucleocytoplasmic shuttling.c-Myc phosphorylation by PKCζ represses prostate tumorigenesis.Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis.Of the atypical PKCs, Par-4 and p62: recent understandings of the biology and pathology of a PB1-dominated complex.Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.Protein kinase C in Wnt signaling: implications in cancer initiation and progression.Protein kinase C and cancer: what we know and what we do not.Rewiring cell polarity signaling in cancer.PKCζ in prostate cancer cells represses the recruitment and M2 polarization of macrophages in the prostate cancer microenvironment.PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity.Protein kinase C in cancer: The top five unanswered questions.Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.Protein kinase C as a tumor suppressor.Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells Control of Paneth Cell Fate, Intestinal Inflammation, and Tumorigenesis by PKCλ/ι.Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.Profiling the interactome of protein kinase C ζ by proteomics and bioinformatics.Protein kinase C: perfectly balanced.PKCα promotes local advancement via its dual roles in nasopharyngeal carcinoma.The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer.Autophagic Regulation of p62 is Critical for Cancer Therapy.

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Protein kinase Czeta represses the interleukin-6 promoter and impairs tumorigenesis in vivo.

http://www.wikidata.org/entity/Q37033601

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 27 October 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

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Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

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type

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Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

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Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

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prefLabel

Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

@en

Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

@nl

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Molecular and Cellular Biology

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Protein kinase Czeta represses ...... impairs tumorigenesis in vivo.

@en

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Angeles Duran

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Anita S Galvez

http://www.w3.org/2001/XMLSchema#string

Elias A Castilla

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Jorge Moscat

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Juan F Linares

http://www.w3.org/2001/XMLSchema#string

Maria T Diaz-Meco

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Michael Leitges

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Peterson Pathrose

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Shadi Abu-Baker

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P2860

The Hallmarks of Cancer

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland

The genomic landscapes of human breast and colorectal cancers

Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway

Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

Shared principles in NF-kappaB signaling

ras oncogenes in human cancer: a review

Tumour-educated macrophages promote tumour progression and metastasis

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104-115

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scholarly article

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10.1128/MCB.01294-08

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1

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29

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2008-10-27T00:00:00Z

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18955501

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2612492

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