Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.
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Systemic VHL gene functions and the VHL diseaseRegulation of human metabolism by hypoxia-inducible factorElimination of von Hippel-Lindau function perturbs pancreas endocrine homeostasis in miceDeletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cellsHypoxia-inducible factor-1alpha regulates beta cell function in mouse and human isletsGlucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cellsOxygen tension regulates pancreatic beta-cell differentiation through hypoxia-inducible factor 1alpha.HIF1α and pancreatic β-cell development.Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.Conditional VHL gene deletion causes hypoglycemic death associated with disproportionately increased glucose uptake by hepatocytes through an upregulated IGF-I receptor.Deletion of the von Hippel-Lindau gene causes sympathoadrenal cell death and impairs chemoreceptor-mediated adaptation to hypoxia.mTOR links incretin signaling to HIF induction in pancreatic beta cells.Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells.New insights into endocrine pancreatic development: the role of environmental factors.Moderate hypoxia induces β-cell dysfunction with HIF-1-independent gene expression changes.Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in miceThe role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action.Dipeptidyl peptidase-4 expression in pancreatic tissue from patients with congenital hyperinsulinismEnhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation.Von Hippel-Lindau disease (VHL): a need for a murine model with retinal hemangioblastomaNormal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function.Decreased serum glucose and glycosylated hemoglobin levels in patients with Chuvash polycythemia: a role for HIF in glucose metabolismImpact of the hypoxia-inducible factor-1 α (HIF1A) Pro582Ser polymorphism on diabetes nephropathy.Hypoxia-inducible factor 1α regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes.Regulation of erythropoiesis by hypoxia-inducible factorsConditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function.Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets.VHL-mediated disruption of Sox9 activity compromises β-cell identity and results in diabetes mellitus.A novel mutation in the von hippel-lindau tumor suppressor gene identified in a patient presenting with gestational diabetes mellitus.Evidence of a metabolic memory to early-life dietary restriction in male C57BL/6 miceA conditional mouse mutant in the tumor suppressor SdhD gene unveils a link between p21(WAF1/Cip1) induction and mitochondrial dysfunction.Microenvironmental stimuli for proliferation of functional islet β-cells.Adipocyte pseudohypoxia suppresses lipolysis and facilitates benign adipose tissue expansion.The Role of Oxidative Stress and Hypoxia in Pancreatic Beta-Cell Dysfunction in Diabetes Mellitus.Crosstalk between the developing pancreas and its blood vessels: an evolving dialog.Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta CellsMaintenance of ischemic β cell viability through delivery of lipids and ATP by targeted liposomes.Hypoxia reduces HNF4α/MODY1 protein expression in pancreatic β-cells by activating AMP-activated protein kinase.Renal injury is accelerated by global hypoxia-inducible factor 1 alpha deficiency in a mouse model of STZ-induced diabetes.
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P2860
Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Deletion of the von Hippel-Lin ...... s glucose homeostasis in mice.
@en
Deletion of the von Hippel-Lin ...... s glucose homeostasis in mice.
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type
label
Deletion of the von Hippel-Lin ...... s glucose homeostasis in mice.
@en
Deletion of the von Hippel-Lin ...... s glucose homeostasis in mice.
@nl
prefLabel
Deletion of the von Hippel-Lin ...... s glucose homeostasis in mice.
@en
Deletion of the von Hippel-Lin ...... s glucose homeostasis in mice.
@nl
P2093
P2860
P50
P356
P1476
Deletion of the von Hippel-Lin ...... rs glucose homeostasis in mice
@en
P2093
Deepa Shukla
Frauke Forstreuter
Henry Asare-Anane
Melanie Clements
Miguel A Esteban
Sarah K Harten
Steven J Lingard
P2860
P304
P356
10.1172/JCI26934
P407
P50
P577
2008-12-08T00:00:00Z