Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism.
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The basics of epithelial-mesenchymal transitionThe Extracellular Matrix in Bronchopulmonary Dysplasia: Target and SourceSchisandrin B attenuates cancer invasion and metastasis via inhibiting epithelial-mesenchymal transitionThe role of integrins in TGFβ activation in the tumour stromaFibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasionTwist: a molecular target in cancer therapeuticsFibromodulin suppresses nuclear factor-kappaB activity by inducing the delayed degradation of IKBA via a JNK-dependent pathway coupled to fibroblast apoptosisActivated Abl kinase inhibits oncogenic transforming growth factor-beta signaling and tumorigenesis in mammary tumors.CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways.Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-CFibulin-3 suppresses Wnt/β-catenin signaling and lung cancer invasion.Fibulin-5 is up-regulated by hypoxia in endothelial cells through a hypoxia-inducible factor-1 (HIF-1α)-dependent mechanism.SNP-SNP interaction network in angiogenesis genes associated with prostate cancer aggressivenessFibulin-5 inhibits hepatocellular carcinoma cell migration and invasion by down-regulating matrix metalloproteinase-7 expressionBCL6 is a negative prognostic factor and exhibits pro-oncogenic activity in ovarian cancer.Oncogenic fibulin-5 promotes nasopharyngeal carcinoma cell metastasis through the FLJ10540/AKT pathway and correlates with poor prognosis.The Cain and Abl of epithelial-mesenchymal transition and transforming growth factor-β in mammary epithelial cellsFibulin-5 inhibits Wnt/β-catenin signaling in lung cancer.Fibulin-5 Regulates Angiopoietin-1/Tie-2 Receptor Signaling in Endothelial Cells.miR-200c is aberrantly expressed in leiomyomas in an ethnic-dependent manner and targets ZEBs, VEGFA, TIMP2, and FBLN5.Effect of fibulin-5 on adhesion, migration and invasion of hepatocellular carcinoma cells via an integrin-dependent mechanism.Expression of E-selectin ligands on circulating tumor cells: cross-regulation with cancer stem cell regulatory pathways?Matrix-dependent perturbation of TGFβ signaling and diseaseFibulin-5 Blocks Microenvironmental ROS in Pancreatic Cancer.Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation.Fibulin-5 localisation in human endometrial cancer shifts from epithelial to stromal with increasing tumour grade, and silencing promotes endometrial epithelial cancer cell proliferation.The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells.Noncanonical TGF-β signaling during mammary tumorigenesis.Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression.The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness.Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression.Fibulin-5, an integrin-binding matricellular protein: its function in development and disease.HIF2α/EFEMP1 cascade mediates hypoxic effects on breast cancer stem cell hierarchy.Epithelial-mesenchymal transition in development and cancer.c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expressionDecreased expression of FOXF2 as new predictor of poor prognosis in stage I non-small cell lung cancer.Connection between inflammation and carcinogenesis in gastrointestinal tract: focus on TGF-beta signaling.Multiple biological functions of Twist1 in various cancers.Functional analysis of candidate genes in 2q13 deletion syndrome implicates FBLN7 and TMEM87B deficiency in congenital heart defects and FBLN7 in craniofacial malformations.Fibulin-5 is a tumour suppressor inhibiting cell migration and invasion in ovarian cancer.
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Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGF-beta in mammary epithelial cells via a MMP-dependent mechanism.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 19 August 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Fibulin-5 initiates epithelial ...... via a MMP-dependent mechanism.
@en
Fibulin-5 initiates epithelial-mesenchymal transition
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type
label
Fibulin-5 initiates epithelial ...... via a MMP-dependent mechanism.
@en
Fibulin-5 initiates epithelial-mesenchymal transition
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prefLabel
Fibulin-5 initiates epithelial ...... via a MMP-dependent mechanism.
@en
Fibulin-5 initiates epithelial-mesenchymal transition
@nl
P2093
P2860
P356
P1433
P1476
Fibulin-5 initiates epithelial ...... via a MMP-dependent mechanism.
@en
P2093
Allan R Albig
Barbara J Schiemann
MaryAnn Regner
William P Schiemann
Yong-Hun Lee
P2860
P304
P356
10.1093/CARCIN/BGN199
P407
P577
2008-08-19T00:00:00Z