Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.
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A deoxyribonucleotidase in mitochondria: involvement in regulation of dNTP pools and possible link to genetic diseasePoint mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouseDiseases associated with immunosuppressionA rat model of purine nucleoside phosphorylase deficiencyDeoxyadenosine triphosphate as a mediator of deoxyguanosine toxicity in cultured T lymphoblastsThe metabolism of deoxyguanosine and guanosine in human B and T lymphoblasts. A role for deoxyguanosine kinase activity in the selective T-cell defect associated with purine nucleoside phosphorylase deficiency2'-deoxyguanosine toxicity for B and mature T lymphoid cell lines is mediated by guanine ribonucleotide accumulationErythrocyte metabolism in purine nucleoside phosphorylase deficiency after enzyme replacement therapy by infusion of erythrocytesMitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient miceHeberden oration 1979: human aberrations of purine metabolism and their significance for rheumatology.Human purine metabolism: some recent advances and relationships with immunodeficiencyEnzyme and membrane markers in leukaemia: recent developmentsPreclinical and clinical evaluation of forodesine in pediatric and adult B-cell acute lymphoblastic leukemiaSevere combined immunodeficiency--molecular pathogenesis and diagnosis.Role of nelarabine in the treatment of T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma.Specific cytotoxicity of arabinosylguanine toward cultured T lymphoblastsEcto-5'-nucleotidase activity in human T cell subsets. Decreased numbers of ecto-5'-nucleotidase positive cells from both OKT4+ and OKT8+ cells in patients with hypogammaglobulinemia.Purine nucleoside phosphorylase deficiency with a novel PNP gene mutation: a first case report from IndiaGuanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine.A beta-fluoroamine inhibitor of purine nucleoside phosphorylasePossible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylasePurinogenic immunodeficiency diseases. Differential effects of deoxyadenosine and deoxyguanosine on DNA synthesis in human T lymphoblasts.In vitro of adenosine on lymphocytes and erythrocytes from horses with combined immunodeficiency.Isolation and characterization of purine-nucleoside phosphorylase-deficient T-lymphoma cells and secondary mutants with altered ribonucleotide reductase: genetic model for immunodeficiency disease.Selective toxicity of purine deoxynucleosides for human lymphocyte growth and function.Biochemical basis for the enhanced toxicity of deoxyribonucleosides toward malignant human T cell linesDeoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.Primary immunodeficiency diseases associated with neurologic manifestations.Transition States, analogues, and drug development.New insights into the synergism of nucleoside analogs with radiotherapyErythrocyte disorders of purine and pyrimidine metabolism.Mechanisms of 2'-deoxyguanosine toxicity in mouse T-lymphoma cells with purine nucleoside phosphorylase deficiency and resistance to inhibition of ribonucleotide reductase by dGTP.Purine deoxynucleosides and adenosine dialdehyde decrease 5-amino-4-imidazolecarboxamide (Z-base)-dependent purine nucleotide synthesis in cultured T and B lymphoblastsAchieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase.Deoxynucleotide-interconverting enzymes and the quantification of deoxynucleoside triphosphates in mammalian cells.Purine nucleoside phosphorylase deficiency associated with a dysplastic marrow morphology.Human placental nucleoside kinase activities.Metabolic interrelations within guanine deoxynucleotide pools for mitochondrial and nuclear DNA maintenance.
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Deoxyguanosine triphosphate as a possible toxic metabolite in the immunodeficiency associated with purine nucleoside phosphorylase deficiency.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 1978
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@en
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@nl
type
label
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@en
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@nl
prefLabel
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@en
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@nl
P2093
P2860
P356
P1476
Deoxyguanosine triphosphate as ...... side phosphorylase deficiency.
@en
P2093
P2860
P304
P356
10.1172/JCI109058
P407
P577
1978-05-01T00:00:00Z