The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents
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Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2The DNA damage response induced by infection with human cytomegalovirus and other virusesEarly Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damageIdentifying core gene modules in glioblastoma based on multilayer factor-mediated dysfunctional regulatory networks through integrating multi-dimensional genomic data.A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway.Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.mTOR controls FLIPS translation and TRAIL sensitivity in glioblastoma multiforme cellsInfluence of cell cycle checkpoints and p53 function on the toxicity of temozolomide in human pancreatic cancer cells.Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response?Morphological analysis of CDC2 and glycogen synthase kinase 3β phosphorylation as markers of g2 → m transition in gliomaEssential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope.Structure and function of the components of the human DNA mismatch repair system.NF-κB is activated in response to temozolomide in an AKT-dependent manner and confers protection against the growth suppressive effect of the drug.The p38 MAPK stress pathway as a tumor suppressor or more?Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implications.Pivotal Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in Inflammatory Pulmonary Diseases.Mismatch repair protein deficiency compromises cisplatin-induced apoptotic signaling.Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.Magnolol and honokiol exert a synergistic anti-tumor effect through autophagy and apoptosis in human glioblastomas.Non-classical p38 map kinase functions: cell cycle checkpoints and survival.Interleukins in glioblastoma pathophysiology: implications for therapy.Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM.Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells.Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival.Influence of DNA repair on nonlinear dose-responses for mutation.Temozolomide induced c-Myc-mediated apoptosis via Akt signalling in MGMT expressing glioblastoma cells.Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta.Cell cycle effects and increased adduct formation by temozolomide enhance the effect of cytotoxic and targeted agents in lung cancer cell lines.Inhibition of c-Jun N-terminal kinase enhances temozolomide-induced cytotoxicity in human glioma cells.TMZ-BioShuttle--a reformulated temozolomide.Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses.MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N'-nitro-N'-nitrosoguanidine.Cyclin B1 proteolysis via p38 MAPK signaling participates in G2 checkpoint elicited by arsenite.Adenine nucleotides inhibit proliferation of the human lung adenocarcinoma cell line LXF-289 by activation of nuclear factor kappaB1 and mitogen-activated protein kinase pathways.A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis.p38γ regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage.DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis.Treatment of glioblastoma multiforme cells with temozolomide-BioShuttle ligated by the inverse Diels-Alder ligation chemistryMismatch Repair Protein hMLH1, but not hMSH2, Enhances Estrogen-Induced Apoptosis of Colon Cancer Cells.
P2860
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P2860
The p38 mitogen-activated protein kinase pathway links the DNA mismatch repair system to the G2 checkpoint and to resistance to chemotherapeutic DNA-methylating agents
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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2003年學術文章
@zh-hant
name
The p38 mitogen-activated prot ...... apeutic DNA-methylating agents
@en
The p38 mitogen-activated prot ...... peutic DNA-methylating agents.
@nl
type
label
The p38 mitogen-activated prot ...... apeutic DNA-methylating agents
@en
The p38 mitogen-activated prot ...... peutic DNA-methylating agents.
@nl
prefLabel
The p38 mitogen-activated prot ...... apeutic DNA-methylating agents
@en
The p38 mitogen-activated prot ...... peutic DNA-methylating agents.
@nl
P2093
P2860
P1476
The p38 mitogen-activated prot ...... apeutic DNA-methylating agents
@en
P2093
Daphne A Haas-Kogan
David Stokoe
Makoto Katayama
Mitchel S Berger
Russell O Pieper
Yuichi Hirose
P2860
P304
P356
10.1128/MCB.23.22.8306-8315.2003
P407
P577
2003-11-01T00:00:00Z