DNA damage response at functional and dysfunctional telomeres
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Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeresGenome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cellsThe DNA-damage response in human biology and diseaseDNA end resection: many nucleases make light workStructure and function of the telomeric CST complexInsertion of Retrotransposons at Chromosome Ends: Adaptive Response to Chromosome MaintenanceDouble-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instabilityTelomere shortening in human diseasesMicronuclei in genotoxicity assessment: from genetics to epigenetics and beyondThe genome-wide transcription response to telomerase deficiency in the thermotolerant yeast Hansenula polymorpha DL-1.Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.Imetelstat, a telomerase inhibitor, differentially affects normal and malignant megakaryopoiesis.A kinase-independent role for the Rad3(ATR)-Rad26(ATRIP) complex in recruitment of Tel1(ATM) to telomeres in fission yeastHuman MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.The Leishmania amazonensis TRF (TTAGGG repeat-binding factor) homologue binds and co-localizes with telomeresTankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenanceRoles of heterochromatin and telomere proteins in regulation of fission yeast telomere recombination and telomerase recruitment.Preserving Yeast Genetic Heritage through DNA Damage Checkpoint Regulation and Telomere Maintenance.The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase.Rif1 supports the function of the CST complex in yeast telomere capping.ATR contributes to telomere maintenance in human cellsQuantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects.To fuse or not to fuse: how do checkpoint and DNA repair proteins maintain telomeres?Telomeres and immunological diseases of agingCanonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4The telomeric protein SNM1B/Apollo is required for normal cell proliferation and embryonic development.Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells.Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1Subtelomere-binding protein Tbf1 and telomere-binding protein Rap1 collaborate to inhibit localization of the Mre11 complex to DNA ends in budding yeast.Alternative arrangements of telomeric recognition sites regulate the binding mode of the DNA-binding domain of yeast Rap1.The breast cancer susceptibility gene BRCA2 is required for the maintenance of telomere homeostasis.Mec1p associates with functionally compromised telomeresJMJD3 promotes SAHF formation in senescent WI38 cells by triggering an interplay between demethylation and phosphorylation of RB protein.CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase.Telomeres, a busy platform for cell signaling.Loss of the histone variant H2A.Z restores capping to checkpoint-defective telomeres in Drosophila.Telomere targeting with a novel G-quadruplex-interactive ligand BRACO-19 induces T-loop disassembly and telomerase displacement in human glioblastoma cells.Sharpening the ends for repair: mechanisms and regulation of DNA resection.
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DNA damage response at functional and dysfunctional telomeres
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on January 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
DNA damage response at functional and dysfunctional telomeres
@en
DNA damage response at functional and dysfunctional telomeres.
@nl
type
label
DNA damage response at functional and dysfunctional telomeres
@en
DNA damage response at functional and dysfunctional telomeres.
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prefLabel
DNA damage response at functional and dysfunctional telomeres
@en
DNA damage response at functional and dysfunctional telomeres.
@nl
P2860
P356
P1433
P1476
DNA damage response at functional and dysfunctional telomeres
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P2093
Maria Pia Longhese
P2860
P304
P356
10.1101/GAD.1626908
P577
2008-01-01T00:00:00Z