Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
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Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cellsFeedback between p21 and reactive oxygen production is necessary for cell senescenceNUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrestCellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cellsMTH1 inhibition eradicates cancer by preventing sanitation of the dNTP poolCrystal structure of human MTH1 and the 8-oxo-dGMP product complexStereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategyATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescenceCritical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides.Sod2 haploinsufficiency does not accelerate aging of telomere dysfunctional miceGlutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsetsFragmentation of electrospray-produced deprotonated ions of oligodeoxyribonucleotides containing an alkylated or oxidized thymidineCreation and validation of a ligation-independent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stressCytosolic malate dehydrogenase regulates senescence in human fibroblasts.Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1.Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel diseaseMTH1 as a Chemotherapeutic Target: The Elephant in the Room.Oxidative stress and DNA lesions: the role of 8-oxoguanine lesions in Trypanosoma cruzi cell viability.MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways.RAS transformation requires CUX1-dependent repair of oxidative DNA damage.The positive effects of Ginsenoside Rg1 upon the hematopoietic microenvironment in a D-Galactose-induced aged rat model.Accelerated hematopoietic stem cell aging in a mouse model of dyskeratosis congenita responds to antioxidant treatment.Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin.Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages.Hormetic effect of rotenone in primary human fibroblasts.Human Mut T Homolog 1 (MTH1): a roadblock for the tumor-suppressive effects of oncogenic RAS-induced ROS.The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damageAmeliorating Effect of Akebia quinata Fruit Extracts on Skin Aging Induced by Advanced Glycation End Products.Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.Anti-Apoptotic and Pro-Survival Effect of Alpinate Oxyphyllae Fructus (AOF) in a d-Galactose-Induced Aging Heart.Oxidative stress-induced mutagenesis in single-strand DNA occurs primarily at cytosines and is DNA polymerase zeta-dependent only for adenines and guanines.Immutable functional attributes of histologic grade revealed by context-independent gene expression in primary breast cancer cells.Prognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.Chronic Low Dose Rate Ionizing Radiation Exposure Induces Premature Senescence in Human Fibroblasts that Correlates with Up Regulation of Proteins Involved in Protection against Oxidative StressMAP kinase phosphatase-1--a new player at the nexus between sarcopenia and metabolic diseaseNever-ageing cellular senescenceTelomeres, oxidative stress and inflammatory factors: partners in cellular senescence?Metabolomics revealed the toxicity of cationic liposomes in HepG2 cells using UHPLC-Q-TOF/MS and multivariate data analysis.Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma.
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Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 31 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Continuous elimination of oxid ...... onset of cellular senescence.
@en
Continuous elimination of oxid ...... onset of cellular senescence.
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type
label
Continuous elimination of oxid ...... onset of cellular senescence.
@en
Continuous elimination of oxid ...... onset of cellular senescence.
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prefLabel
Continuous elimination of oxid ...... onset of cellular senescence.
@en
Continuous elimination of oxid ...... onset of cellular senescence.
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P2093
P2860
P50
P356
P1476
Continuous elimination of oxid ...... onset of cellular senescence.
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P2093
Jennifer J Young
Jose L McFaline
Tamer T Onder
P2860
P304
P356
10.1073/PNAS.0809834106
P407
P577
2008-12-31T00:00:00Z