Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
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Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilizationBH3 domains other than Bim and Bid can directly activate Bax/BakWrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsPUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosisCancer's Achilles' Heel: Apoptosis and Necroptosis to the RescueThe paradox role of caspase cascade in ionizing radiation therapyPutting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependentA stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.Desflurane preconditioning induces oscillation of NF-κB in human umbilical vein endothelial cellsNavitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity.Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis inductionAntiproliferative and Proapoptotic Activities of Marine Sponge Hyrtios erectus Extract on Breast Carcinoma Cell Line (MCF-7).Manumycin induces apoptosis in prostate cancer cellsAcquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.Oxaliplatin long-circulating liposomes improved therapeutic index of colorectal carcinoma.Bax forms an oligomer via separate, yet interdependent, surfaces.Phytochemicals: a multitargeted approach to gynecologic cancer therapy.Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer.Genome wide DNA copy number analysis of serous type ovarian carcinomas identifies genetic markers predictive of clinical outcome.Using the neurofibromatosis tumor predisposition syndromes to understand normal nervous system development.Coordination between cell cycle progression and cell fate decision by the p53 and E2F1 pathways in response to DNA damage.Delivery of a monomeric p53 subdomain with mitochondrial targeting signals from pro-apoptotic Bak or Bax.B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins.Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry.Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea.The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment.The BCL-2 family reunion.BID is a critical factor controlling cell viability regulated by IFN-α.Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressorProtective Effect of Neuropeptide Substance P on Bone Marrow Mesenchymal Stem Cells against Apoptosis Induced by Serum DeprivationSensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locationsInhibition of Mcl-1 promotes senescence in cancer cells: implications for preventing tumor growth and chemotherapy resistance.Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview.Acidic pH promotes oligomerization and membrane insertion of the BclXL apoptotic repressor.Sphingolipid metabolism cooperates with BAK and BAX to promote the mitochondrial pathway of apoptosisMechanism of neem limonoids-induced cell death in cancer: Role of oxidative phosphorylation.Where killers meet--permeabilization of the outer mitochondrial membrane during apoptosis.
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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 12 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
@en
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.
@nl
type
label
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
@en
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.
@nl
prefLabel
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
@en
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.
@nl
P2093
P2860
P356
P1476
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
@en
P2093
Christopher P Dillon
John C Fisher
Richard W Kriwacki
Tomomi Kuwana
P2860
P304
20327-20332
P356
10.1073/PNAS.0808036105
P407
P577
2008-12-12T00:00:00Z