3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.
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Substrate recognition by complement convertases revealed in the C5-cobra venom factor complexStructures of C3b in complex with factors B and D give insight into complement convertase formationDesign and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseasesPutting the structure into complementInsights into complement convertase formation based on the structure of the factor B-cobra venom factor complexStructural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitorAncylostoma ceylanicum Excretory–Secretory Protein 2 Adopts a Netrin-Like Fold and Defines a Novel Family of Nematode ProteinsA humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factorsStructural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation.Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulation.Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease riskAllelic variants of complement genes associated with dense deposit disease.Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopyAccess to the complement factor B scissile bond is facilitated by association of factor B with C3b protein.Role of complement and complement regulatory proteins in the complications of diabetesA Familial C3GN Secondary to Defective C3 Regulation by Complement Receptor 1 and Complement Factor HComplement activation, regulation, and molecular basis for complement-related diseasesAssembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy imagesProgress and Trends in Complement TherapeuticsInsights into the Effects of Complement Factor H on the Assembly and Decay of the Alternative Pathway C3 Proconvertase and C3 Convertase.How novel structures inform understanding of complement function.Complement component 3: characterization and association with mastitis resistance in Egyptian water buffalo and cattle.The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.The outer membrane protease PgtE of Salmonella enterica interferes with the alternative complement pathway by cleaving factors B and H.Solution Structures of Complement C2 and Its C4 Complexes Propose Pathway-specific Mechanisms for Control and Activation of the Complement Proconvertases.Interaction between Multimeric von Willebrand Factor and Complement: A Fresh Look to the Pathophysiology of Microvascular Thrombosis.
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3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 09 January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
3D structure of the C3bB compl ...... lternative pathway convertase.
@en
3D structure of the C3bB compl ...... lternative pathway convertase.
@nl
type
label
3D structure of the C3bB compl ...... lternative pathway convertase.
@en
3D structure of the C3bB compl ...... lternative pathway convertase.
@nl
prefLabel
3D structure of the C3bB compl ...... lternative pathway convertase.
@en
3D structure of the C3bB compl ...... lternative pathway convertase.
@nl
P2860
P50
P356
P1476
3D structure of the C3bB compl ...... alternative pathway convertase
@en
P2093
Eva Torreira
Tamara Montes
P2860
P304
P356
10.1073/PNAS.0810860106
P407
P577
2009-01-09T00:00:00Z