The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity. - Wikidata - wikimedia - TriplyDB

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

http://www.wikidata.org/entity/Q39968584

about

Complement in age-related macular degeneration: a focus on function The complotype: dictating risk for inflammation and infection A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors Genetic influences on plasma CFH and CFHR1 concentrations and their role in susceptibility to age-related macular degeneration Genetics and complement in atypical HUS.Disease-associated N-terminal complement factor H mutations perturb cofactor and decay-accelerating activities.Factors determining penetrance in familial atypical haemolytic uraemic syndrome.The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency.A haplotype in CFH family genes confers high risk of rare glomerular nephropathies.Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility.Complement control protein factor H: the good, the bad, and the inadequate.Whole-exome sequencing identifies rare, functional CFH variants in families with macular degeneration.Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.Characterization of a factor H mutation that perturbs the alternative pathway of complement in a family with membranoproliferative GN.The significance of the complement system for the pathogenesis of age-related macular degeneration - current evidence and translation into clinical application Complement factor B polymorphism 32W protects against age-related macular degeneration.Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk Dense deposit disease.Allelic variants of complement genes associated with dense deposit disease.Copy number variation in the complement factor H-related genes and age-related macular degeneration Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis Complement component 5 contributes to poor disease outcome in humans and mice with pneumococcal meningitis.Age-Related Macular Degeneration: A Disease of Systemic or Local Complement Dysregulation?Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus.Complement factor H Val62Ile variant and risk of age-related macular degeneration: a meta-analysis.Sensitive and specific assays for C3 nephritic factors clarify mechanisms underlying complement dysregulation Insights into the Effects of Complement Factor H on the Assembly and Decay of the Alternative Pathway C3 Proconvertase and C3 Convertase.Regulators of complement activity mediate inhibitory mechanisms through a common C3b-binding mode.Sequence and Expression of Complement Factor H Gene Cluster Variants and Their Roles in Age-Related Macular Degeneration Risk.Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia Genetic control of the alternative pathway of complement in humans and age-related macular degeneration CFH haplotypes and ARMS2, C2, C3, and CFB alleles show association with susceptibility to age-related macular degeneration in Mexicans.C3 glomerulopathy: a new classification.How novel structures inform understanding of complement function.A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma.The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement.Disease-linked mutations in factor H reveal pivotal role of cofactor activity in self-surface-selective regulation of complement activation.A Novel Complotype Combination Associates with Age-Related Macular Degeneration and High Complement Activation Levels in vivo.Genetic modifier loci of mouse Mfrp(rd6) identified by quantitative trait locus analysis.

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P2860

The disease-protective complement factor H allotypic variant Ile62 shows increased binding affinity for C3b and enhanced cofactor activity.

http://www.wikidata.org/entity/Q39968584

description

2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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2009年學術文章

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2009年學術文章

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name

The disease-protective complem ...... nd enhanced cofactor activity.

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The disease-protective complem ...... nd enhanced cofactor activity.

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type

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The disease-protective complem ...... nd enhanced cofactor activity.

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The disease-protective complem ...... nd enhanced cofactor activity.

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The disease-protective complem ...... nd enhanced cofactor activity.

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The disease-protective complem ...... nd enhanced cofactor activity.

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Human Molecular Genetics

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The disease-protective complem ...... nd enhanced cofactor activity.

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P2093

B Paul Morgan

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Claire L Harris

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Rubén Martínez-Barricarte

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Santiago Rodríguez de Córdoba

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Tamara Montes

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P2860

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II)

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Complement factor H polymorphism in age-related macular degeneration

Control of the amplification convertase of complement by the plasma protein beta1H

Structure of the N-terminal region of complement factor H and conformational implications of disease-linked sequence variations

Human complement C3b inactivator: isolation, characterization, and demonstration of an absolute requirement for the serum protein beta1H for cleavage of C3b and C4b in solution

A simple salting out procedure for extracting DNA from human nucleated cells

Complement factor H variant increases the risk of age-related macular degeneration

The human complement factor H: functional roles, genetic variations and disease associations

Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degeneration

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3452-3461

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10.1093/HMG/DDP289

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18

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18

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Agustín Tortajada

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2009-06-23T00:00:00Z

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26314098

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19549636

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3272369

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