Fluorometric measurements of conformational changes in glutamate transporters.
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Strong cooperativity between subunits in voltage-gated proton channelsThe glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunitsVisualizing functional motions of membrane transporters with molecular dynamics simulationsCurrent approaches to enhance glutamate transporter function and expressionExcitatory amino acid transporters: roles in glutamatergic neurotransmissionStructure of a glutamate transporter homologue from Pyrococcus horikoshii.Fluorescence applications in molecular neurobiologyMapping membrane protein structure with fluorescence.Intrinsic kinetics determine the time course of neuronal synaptic transporter currents.Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.Correlating charge movements with local conformational changes of a Na(+)-coupled cotransporterNormal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.Evidence for a third sodium-binding site in glutamate transporters suggests an ion/substrate coupling model.Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter.EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptakeNew views of glutamate transporter structure and function: advances and challenges.Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrateVoltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry.Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement.Electrogenic glutamate transporters in the CNS: molecular mechanism, pre-steady-state kinetics, and their impact on synaptic signaling.Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter.Voltage clamp fluorometric measurements on a type II Na+-coupled Pi cotransporter: shedding light on substrate binding order.Conformational dynamics of hSGLT1 during Na+/glucose cotransportCooperation of the conserved aspartate 439 and bound amino acid substrate is important for high-affinity Na+ binding to the glutamate transporter EAAC1Aspartate-444 is essential for productive substrate interactions in a neuronal glutamate transporter.Kinetic relationship between the voltage sensor and the activation gate in spHCN channelsPatch fluorometry: shedding new light on ion channels.Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.The beta subunit of the Na+/K+-ATPase follows the conformational state of the holoenzyme.Voltage Clamp Fluorometry of P-Type ATPases.Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1.Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter.The α2δ-1 subunit remodels CaV1.2 voltage sensors and allows Ca2+ influx at physiological membrane potentialsMutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes.Conformational changes associated with proton-dependent gating of ASIC1a.Neurotransmitter transporters: structure meets function.Astrocyte sodium signaling and the regulation of neurotransmission.Gating Charge Calculations by Computational Electrophysiology Simulations.
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Fluorometric measurements of conformational changes in glutamate transporters.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 04 March 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Fluorometric measurements of conformational changes in glutamate transporters.
@en
Fluorometric measurements of conformational changes in glutamate transporters.
@nl
type
label
Fluorometric measurements of conformational changes in glutamate transporters.
@en
Fluorometric measurements of conformational changes in glutamate transporters.
@nl
prefLabel
Fluorometric measurements of conformational changes in glutamate transporters.
@en
Fluorometric measurements of conformational changes in glutamate transporters.
@nl
P2093
P2860
P356
P1476
Fluorometric measurements of conformational changes in glutamate transporters.
@en
P2093
Anastassios V Tzingounis
H Peter Larsson
Hans P Koch
Michael P Kavanaugh
P2860
P304
P356
10.1073/PNAS.0306737101
P407
P577
2004-03-04T00:00:00Z