Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
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X-ray Crystallographic Analysis of α-Ketoheterocycle Inhibitors Bound to a Humanized Variant of Fatty Acid Amide HydrolaseCrystal Structure of Fatty Acid Amide Hydrolase Bound to the Carbamate Inhibitor URB597: Discovery of a Deacylating Water Molecule and Insight into Enzyme InactivationFluoride-Mediated Capture of a Noncovalent Bound State of a Reversible Covalent Enzyme Inhibitor: X-ray Crystallographic Analysis of an Exceptionally Potent α-Ketoheterocycle Inhibitor of Fatty Acid Amide HydrolaseInhibitors of Fatty Acid Amide Hydrolase and Monoacylglycerol Lipase: New Targets for Future AntidepressantsFatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disordersApproximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase.The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).A second generation of carbamate-based fatty acid amide hydrolase inhibitors with improved activity in vivoStructure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability.Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography.Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation.Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation.Computational methods for the discovery of mood disorder therapies.Recent advances in the discovery and evaluation of fatty acid amide hydrolase inhibitors.Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stabilityO-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors.Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors.
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Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 29 May 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates.
@en
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates.
@nl
type
label
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates.
@en
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates.
@nl
prefLabel
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates.
@en
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates.
@nl
P2093
P2860
P50
P356
P1476
Synthesis and quantitative str ...... biphenyl-3-yl alkylcarbamates
@en
P2093
Alvin R King
Andrea Duranti
Andrea Tontini
Daniele Piomelli
Giorgio Tarzia
Jason R Clapper
Silvano Sanchini
P2860
P304
P356
10.1021/JM701631Z
P407
P577
2008-05-29T00:00:00Z