Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model
about
Phosphorylation of microtubule-associated protein tau by AMPK-related kinasesRescue from tau-induced neuronal dysfunction produces insoluble tau oligomersTau physiology and pathomechanisms in frontotemporal lobar degenerationModeling the complex pathology of Alzheimer's disease in DrosophilaInteraction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogasterInteractions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease.Identification of oligomers at early stages of tau aggregation in Alzheimer's disease.MARK4 and MARK3 associate with early tau phosphorylation in Alzheimer's disease granulovacuolar degeneration bodies.Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology.Transgenic Drosophila models of Alzheimer's disease and tauopathiesAlzheimer's disease: insights from Drosophila melanogaster models.A DNA damage-activated checkpoint kinase phosphorylates tau and enhances tau-induced neurodegeneration.ASIP Outstanding Investigator Award Lecture. New approaches to the pathology and genetics of neurodegenerationTau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease.Drosophila melanogaster in the study of human neurodegeneration.The role of tau kinases in Alzheimer's disease.Drosophila melanogaster as a model organism for Alzheimer's disease.Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation.The toxicity of tau in Alzheimer disease: turnover, targets and potential therapeuticsCommon Polymorphisms in the GSK3β Gene May Contribute to the Pathogenesis of Alzheimer Disease: A Meta-Analysis.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy.Drosophila models of proteinopathies: the little fly that could.Stabilization of Microtubule-Unbound Tau via Tau Phosphorylation at Ser262/356 by Par-1/MARK Contributes to Augmentation of AD-Related Phosphorylation and Aβ42-Induced Tau Toxicity.Drosophila models of tauopathies: what have we learned?Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative diseaseThe CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylationRecent advances in using Drosophila to model neurodegenerative diseases.Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease.Alzheimer's disease and tauopathy studies in flies and worms.Screening of treatment targets for Alzheimer's disease from the molecular mechanisms of impairment by β-amyloid aggregation and tau hyperphosphorylation.The power and richness of modelling tauopathies in Drosophila.Functional implications of glycogen synthase kinase-3-mediated tau phosphorylationReview: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.Modelling tauopathies in Drosophila: insights from the fruit fly.Using Drosophila models of neurodegenerative diseases for drug discovery.Tau-induced neurodegeneration: mechanisms and targets.Invited review: Animal models of tauopathies and their implications for research/translation into the clinic.Cellular and molecular modifier pathways in tauopathies: the big picture from screening invertebrate models.TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo.
P2860
Q24292882-75DB66BB-0578-4197-BFAF-9C520D6BC04AQ27305025-0CD72C87-273B-4D97-AF8D-25CCB6F76029Q28070250-4EA5113C-5096-4FF8-81CC-4C7BDABBA34AQ28082451-4B66E16E-1EAA-4C55-A424-C175EDC9BC17Q30434694-5BEA8B87-E8B6-49D9-ACF0-4C6E8EF0C0BCQ30577687-6E53B889-671D-4DB2-9ED8-DEFBD200A946Q33713341-51BD37FC-7336-4849-9521-D310E13C0AAAQ33715568-77C499FF-F1AC-46B2-989D-3653881D3C93Q33726405-624D312B-B940-4511-8C18-956E284845A7Q33770749-82D7A9ED-0D73-4776-A481-43F1FD28EC67Q33799241-4AD818EB-124D-474A-9E52-EA6610B5EB66Q33815578-DD4D3932-AA7D-48C3-9CBA-66BDD287C32BQ33816233-E970F75D-2E0D-476B-965F-41F61A8AFD14Q33980306-47B8F9F0-DC59-4B09-9CD5-7937CA5B5EE6Q34022667-6983866D-1EAB-4533-BB9B-3753F66127B8Q34138413-2DBCF455-A6AE-4DDE-B8C2-B9FD0180B0FAQ34464181-205236DA-FFD0-4257-93A2-5232B21AE3BDQ35012356-1127C7AE-A803-48DF-960F-0FCC0683365DQ35216140-434670AD-0633-4A62-BCEB-80022D3A58BFQ35373154-18C017AF-EB90-4F1A-A4E7-48DAD77BD37FQ35565682-09B294C8-77D5-4F42-B39B-A53650C0C515Q35747174-46609EB0-9420-4244-A327-BF5EE29E5548Q35791494-17570C33-6202-4AC9-8874-1CC0F272112DQ35972860-F78F5455-4FEF-43DA-AD34-7B201C7C8740Q36026426-DF74C885-6C66-4CA4-8C97-7FBD934B0733Q37031161-A5DE0071-80D0-4412-918E-E5A7AC84AE00Q37200468-E6527A42-BFA4-4A78-9FF4-0349859EF4E2Q37448324-416A9BBF-5895-4C1A-B105-259CCEF9C1F5Q37630546-4414E486-3D54-4C97-91A7-D4585DC26854Q37715058-351F2856-52DE-41B1-B23D-1E11D58B94D0Q37832656-BFCD8699-B851-470E-8FDA-E15297C46ABDQ37890901-F8519841-4993-4676-8EEC-EEB7CCFA2B37Q37903257-CA8E3B13-4AB9-41D7-8AF4-5118BF96AB44Q37955915-D6E983BF-2B6C-42ED-A24C-54EF2A15AD80Q37976706-FDE465DF-9256-4351-9A8E-76A1C6517D13Q38014579-116D882C-EB07-48EB-A5CB-0D963F034A64Q38204720-C659896D-EB58-4859-8E72-FE5B48DA5311Q38271896-DF05B803-8351-4F62-9924-5F7FB5C45F38Q38693201-85FFB80C-3072-4EB9-B6CE-35B6DB38D053Q39084422-F7D3DEA2-9004-4124-A60F-A54751ADCC18
P2860
Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Dissociation of tau toxicity a ...... and Cdk5 in a Drosophila model
@en
Dissociation of tau toxicity a ...... nd Cdk5 in a Drosophila model.
@nl
type
label
Dissociation of tau toxicity a ...... and Cdk5 in a Drosophila model
@en
Dissociation of tau toxicity a ...... nd Cdk5 in a Drosophila model.
@nl
prefLabel
Dissociation of tau toxicity a ...... and Cdk5 in a Drosophila model
@en
Dissociation of tau toxicity a ...... nd Cdk5 in a Drosophila model.
@nl
P2093
P2860
P356
P1476
Dissociation of tau toxicity a ...... and Cdk5 in a Drosophila model
@en
P2093
George M Lawless
George R Jackson
Shreyasi Chatterjee
P2860
P304
P356
10.1093/HMG/DDN326
P577
2008-10-17T00:00:00Z