CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance - Wikidata - wikimedia - TriplyDB

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

http://www.wikidata.org/entity/Q37106789

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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4 Human T regulatory cell therapy: take a billion or so and call me in the morning Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition CD28 co-stimulation in T-cell homeostasis: a recent perspective Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network Regulatory T cells: mechanisms of differentiation and function The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta CD28 and ITK signals regulate autoreactive T cell trafficking.FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells.Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.CD4(+)CD25(+) T regulatory cells inhibit CD8(+) IFN-gamma production during acute and chronic FIV infection utilizing a membrane TGF-beta-dependent mechanism.Natural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients.Foxo transcription factors control regulatory T cell development and function Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels.Immune tolerance induction by integrating innate and adaptive immune regulators.Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).Antibody therapies for melanoma: new and emerging opportunities to activate immunity (Review).Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection Use of nonobese diabetic mice to understand human type 1 diabetes Induction of T cell anergy: integration of environmental cues and infectious tolerance.Evidence for CTLA4 as a susceptibility gene for dilated cardiomyopathy In vitro HIV infection impairs the capacity of myeloid dendritic cells to induce regulatory T cells.Gene expression profile of peripheral blood lymphocytes from renal cell carcinoma patients treated with IL-2, interferon-α and dendritic cell vaccine.HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells.Human regulatory T cells rapidly suppress T cell receptor-induced Ca(2+), NF-κB, and NFAT signaling in conventional T cells.Human CD14+ CTLA-4+ regulatory dendritic cells suppress T-cell response by cytotoxic T-lymphocyte antigen-4-dependent IL-10 and indoleamine-2,3-dioxygenase production in hepatocellular carcinoma.Differential CTLA-4 expression in human CD4+ versus CD8+ T cells is associated with increased NFAT1 and inhibition of CD4+ proliferation.Co-expression of TNFR2 and CD25 identifies more of the functional CD4+FOXP3+ regulatory T cells in human peripheral blood.Natural killer cells and regulatory T cells in early pregnancy loss.The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function Foxp3(+) regulatory T cell expansion required for sustaining pregnancy compromises host defense against prenatal bacterial pathogens Defects in the Bcl-2-regulated apoptotic pathway lead to preferential increase of CD25 low Foxp3+ anergic CD4+ T cells.Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction.Higher proportions of circulating FOXP3+ and CTLA-4+ regulatory T cells are associated with lower fractions of memory CD4+ T cells in infants.Mechanistic Assessment of PD-1H Coinhibitory Receptor-Induced T Cell Tolerance to Allogeneic Antigens.Beyond adjuvants: immunomodulation strategies to enhance T cell immunity Molecular mechanisms of induction of antigen-specific allograft tolerance by intranasal peptide administration.Ligation of cytotoxic T lymphocyte antigen-4 to T cell receptor inhibits T cell activation and directs differentiation into Foxp3+ regulatory T cells

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

http://www.wikidata.org/entity/Q37106789

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 02 February 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

@en

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.

@nl

type

label

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

@en

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.

@nl

prefLabel

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

@en

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance.

@nl

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Journal of Experimental Medicine

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CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

@en

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Cynthia A Chambers

http://www.w3.org/2001/XMLSchema#string

David S Brown

http://www.w3.org/2001/XMLSchema#string

Hai Nguyen

http://www.w3.org/2001/XMLSchema#string

Hardy Kornfeld

http://www.w3.org/2001/XMLSchema#string

Jinhee Lee

http://www.w3.org/2001/XMLSchema#string

Mark Appleby

http://www.w3.org/2001/XMLSchema#string

Randall H Friedline

http://www.w3.org/2001/XMLSchema#string

Sandy D Der

http://www.w3.org/2001/XMLSchema#string

Yi Zhang

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

CTLA-4 ligation blocks CD28-dependent T cell activation

Structure of murine CTLA-4 and its role in modulating T cell responsiveness

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

Reversal of the TCR stop signal by CTLA-4

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism

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421-434

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scholarly article

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10.1084/JEM.20081811

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2

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206

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2009-02-02T00:00:00Z

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23972587

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19188497

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2646578

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