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Generation of supercoils in nicked and gapped DNA drives DNA unknotting and postreplicative decatenationThe ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks.The dynamic interplay between DNA topoisomerases and DNA topology.Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIαDNA supercoiling and its role in DNA decatenation and unknotting.The use of divalent metal ions by type II topoisomerases.Relationship of DNA damage signaling to DNA replication following treatment with DNA topoisomerase inhibitors camptothecin/topotecan, mitoxantrone, or etoposideRole of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanismBacillus anthracis GrlAV96A topoisomerase IV, a quinolone resistance mutation that does not affect the water-metal ion bridgeMerging and scoring molecular interactions utilising existing community standards: tools, use-cases and a case study.Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplificationLocal sensing of global DNA topology: from crossover geometry to type II topoisomerase processivityDrug interactions with Bacillus anthracis topoisomerase IV: biochemical basis for quinolone action and resistance.Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives.Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance.Local site preference rationalizes disentangling by DNA topoisomerases.Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.Bullied no more: when and how DNA shoves proteins around.Epimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.Insights into Genome Architecture Deduced from the Properties of Short Lac Repressor-mediated DNA Loops.Topoisomerase II and leukemia.Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons.Physics of DNA: unravelling hidden abilities encoded in the structure of ‘the most important molecule’.Crossing-sign discrimination and knot-reduction for a lattice model of strand passage.Etoposide quinone is a covalent poison of human topoisomerase IIβ.Influence of Rigidity and Knot Complexity on the Knotting of Confined Polymers.Topoisomerase IB-DNA interactions: X marks the spotRoles of DNA looping in enhancer-blocking activity.An Anisotropic Effective Model for the Simulation of Semiflexible Ring Polymers.Effect of Bending Rigidity on the Knotting of a Polymer under Tension.Topo2008: DNA topoisomerases in biology and medicine.Searching target sites on DNA by proteins: Role of DNA dynamics under confinement.Cluster-based molecular docking study for in silico identification of novel 6-fluoroquinolones as potential inhibitors against Mycobacterium tuberculosis.Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance.Activities of gyrase and topoisomerase IV on positively supercoiled DNA.A Topology-Centric View on Mitotic Chromosome Architecture.The Dynamic Interplay Between DNA Topoisomerases and DNA Topology.Centromeric Cohesin: Molecular Glue and Much More.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on February 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The why and how of DNA unlinking
@en
The why and how of DNA unlinking.
@nl
type
label
The why and how of DNA unlinking
@en
The why and how of DNA unlinking.
@nl
prefLabel
The why and how of DNA unlinking
@en
The why and how of DNA unlinking.
@nl
P2093
P2860
P356
P1476
The why and how of DNA unlinking
@en
P2093
Hue Sun Chan
Lynn Zechiedrich
Richard W Deibler
Zhirong Liu
P2860
P304
P356
10.1093/NAR/GKP041
P407
P577
2009-02-01T00:00:00Z