Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.
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Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brainCholesterol balance in prion diseases and Alzheimer's diseaseDifferential contributions of ApoE4 and female sex to BACE1 activity and expression mediate Aβ deposition and learning and memory in mouse models of Alzheimer's diseaseCytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesisMemory impairment in transgenic Alzheimer mice requires cellular prion protein.Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearanceACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.Sex differences in β-amyloid accumulation in 3xTg-AD mice: role of neonatal sex steroid hormone exposureThe aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.Gender, sex steroid hormones, and Alzheimer's disease.APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease.Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice.Regulation of cerebral cholesterol metabolism in Alzheimer disease.Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships?Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis.24(S)-Hydroxycholesterol as a Modulator of Neuronal Signaling and Survival.Estrogens, Neuroinflammation, and Neurodegeneration.Cellular Cholesterol Homeostasis in Alzheimer's Disease.Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease.Evidence for premature lipid raft aging in APP/PS1 double-transgenic mice, a model of familial Alzheimer disease.Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis.
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P2860
Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 09 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Reduction of cholesterol synth ...... ase, but does extend lifespan.
@en
Reduction of cholesterol synth ...... ase, but does extend lifespan.
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type
label
Reduction of cholesterol synth ...... ase, but does extend lifespan.
@en
Reduction of cholesterol synth ...... ase, but does extend lifespan.
@nl
prefLabel
Reduction of cholesterol synth ...... ase, but does extend lifespan.
@en
Reduction of cholesterol synth ...... ase, but does extend lifespan.
@nl
P2860
P356
P1476
Reduction of cholesterol synth ...... ase, but does extend lifespan.
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P2093
David W Russell
Rebekkah W Halford
P2860
P304
P356
10.1073/PNAS.0813349106
P407
P577
2009-02-09T00:00:00Z