R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation. - Wikidata - wikimedia - TriplyDB

R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.

R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.

http://www.wikidata.org/entity/Q37117728

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Out of balance: R-loops in human disease Topoisomerase I in Human Disease Pathogenesis and Treatments From UBE3A to Angelman syndrome: a substrate perspective Fragile X spectrum disorders Breaking bad: R-loops and genome integrity Repeat-mediated genetic and epigenetic changes at the FMR1 locus in the Fragile X-related disorders The prospect of molecular therapy for Angelman syndrome and other monogenic neurologic disorders Epigenetic mechanisms in diurnal cycles of metabolism and neurodevelopment Transcription-associated R-loop formation across the human FMR1 CGG-repeat region Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma Angelman syndrome: A review highlighting musculoskeletal and anatomical aberrations.S1-DRIP-seq identifies high expression and polyA tracts as major contributors to R-loop formation.Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders.Reversing chromatin accessibility differences that distinguish homologous mitotic metaphase chromosomes.Long noncoding RNAs in imprinting and X chromosome inactivation.Mechanisms of genome instability induced by RNA-processing defects.A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip Genome-wide distribution of RNA-DNA hybrids identifies RNase H targets in tRNA genes, retrotransposons and mitochondria Highly restricted deletion of the SNORD116 region is implicated in Prader-Willi Syndrome.Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model Head-to-head antisense transcription and R-loop formation promotes transcriptional activation.DNA methylation differences in monozygotic twin pairs discordant for schizophrenia identifies psychosis related genes and networks.Repeat-mediated epigenetic dysregulation of the FMR1 gene in the fragile X-related disorders.Angelman Syndrome.Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters The Yin and Yang of R-loop biology.Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Prevalent, Dynamic, and Conserved R-Loop Structures Associate with Specific Epigenomic Signatures in Mammals.Non-coding RNAs in chromatin disease involving neurological defects The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability.Angelman syndrome: review of clinical and molecular aspects.Transcription and recombination: when RNA meets DNA.Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation.A role for chromatin topology in imprinted domain regulation.R-loop: an emerging regulator of chromatin dynamics.R Loops and Links to Human Disease.Topoisomerases and the regulation of neural function.

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R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation.

http://www.wikidata.org/entity/Q37117728

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 05 August 2013

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vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

R-loop formation at Snord116 m ...... ific chromatin decondensation.

@en

R-loop formation at Snord116 m ...... ific chromatin decondensation.

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type

label

R-loop formation at Snord116 m ...... ific chromatin decondensation.

@en

R-loop formation at Snord116 m ...... ific chromatin decondensation.

@nl

prefLabel

R-loop formation at Snord116 m ...... ific chromatin decondensation.

@en

R-loop formation at Snord116 m ...... ific chromatin decondensation.

@nl

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PNAS.1305426110

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Proceedings of the National Academy of Sciences of the United States of America

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R-loop formation at Snord116 m ...... cific chromatin decondensation

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Dag H Yasui

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Florence K Crary

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Michael L Gonzales

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Nazumi Alice Yamada

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Peter Tsang

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Robert A Ach

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Rochelle L Coulson

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Sarrita Adams

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P2860

Deletion of the MBII-85 snoRNA gene cluster in mice results in postnatal growth retardation

SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

UBE3A/E6-AP mutations cause Angelman syndrome

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C/D box small nucleolar RNA cluster

A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism

Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog

The IC-SNURF-SNRPN transcript serves as a host for multiple small nucleolar RNA species and as an antisense RNA for UBE3A

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13938-13943

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scholarly article

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10.1073/PNAS.1305426110

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34

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110

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Janine M. LaSalle

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2013-08-05T00:00:00Z

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255690140

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23918391

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3752217

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