A conserved hydrophobic tetrad near the C terminus of the secretory Na+-K+-2Cl- cotransporter (NKCC1) is required for its correct intracellular processing.
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Molecular regulation of NKCC2 in the thick ascending limbDevelopmental and functional studies of the SLC12 gene family members from Drosophila melanogaster.Decreased chloride channel expression in the dorsolateral prefrontal cortex in schizophrenia.Impact of Hybrid and Complex N-Glycans on Cell Surface Targeting of the Endogenous Chloride Cotransporter Slc12a2.Impairment of TRPC1-STIM1 channel assembly and AQP5 translocation compromise agonist-stimulated fluid secretion in mice lacking caveolin1COMMD1 interacts with the COOH terminus of NKCC1 in Calu-3 airway epithelial cells to modulate NKCC1 ubiquitination.A patient with multisystem dysfunction carries a truncation mutation in human SLC12A2, the gene encoding the Na-K-2Cl cotransporter, NKCC1.Physiology and pathophysiology of SLC12A1/2 transporters.Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.Mutations in the carboxyl-terminal SEC24 binding motif of the serotonin transporter impair folding of the transporter.A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2.Evolution of the cation chloride cotransporter family: ancient origins, gene losses, and subfunctionalization through duplication.Transit defect of potassium-chloride Co-transporter 3 is a major pathogenic mechanism in hereditary motor and sensory neuropathy with agenesis of the corpus callosum.K+-Cl- co-transporter 2 (KCC2) - a membrane trafficking perspective.
P2860
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P2860
A conserved hydrophobic tetrad near the C terminus of the secretory Na+-K+-2Cl- cotransporter (NKCC1) is required for its correct intracellular processing.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 January 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A conserved hydrophobic tetrad ...... rect intracellular processing.
@en
A conserved hydrophobic tetrad ...... tory Na+-K+-2Cl- cotransporter
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type
label
A conserved hydrophobic tetrad ...... rect intracellular processing.
@en
A conserved hydrophobic tetrad ...... tory Na+-K+-2Cl- cotransporter
@nl
prefLabel
A conserved hydrophobic tetrad ...... rect intracellular processing.
@en
A conserved hydrophobic tetrad ...... tory Na+-K+-2Cl- cotransporter
@nl
P2093
P2860
P356
P1476
A conserved hydrophobic tetrad ...... rect intracellular processing.
@en
P2093
Akihiro Nezu
Most Nahid Parvin
R James Turner
P2860
P304
P356
10.1074/JBC.M804302200
P407
P577
2009-01-07T00:00:00Z