Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells. - Wikidata - wikimedia - TriplyDB

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.

Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.

http://www.wikidata.org/entity/Q37122075

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The transcription factor p53: not a repressor, solely an activator The p53-p21-DREAM-CDE/CHR pathway regulates G2/M cell cycle genes Quantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional Assay Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cells Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms.∆N-P63α and TA-P63α exhibit intrinsic differences in transactivation specificities that depend on distinct features of DNA target sites.Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3 Inhibitory effect of gene combination in a mouse model of colon cancer with liver metastasis.Clustered and genome-wide transient mutagenesis in human cancers: Hypermutation without permanent mutators or loss of fitness Cell context dependent p53 genome-wide binding patterns and enrichment at repeats.p53 binding to human genome: crowd control navigation in chromatin context Interactions of chromatin context, binding site sequence content, and sequence evolution in stress-induced p53 occupancy and transactivation.TP53 engagement with the genome occurs in distinct local chromatin environments via pioneer factor activity iRegulon: from a gene list to a gene regulatory network using large motif and track collections.Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes Evolution of p53 transactivation specificity through the lens of a yeast-based functional assay Whole-genome cartography of p53 response elements ranked on transactivation potential.Integrative genomic analysis reveals widespread enhancer regulation by p53 in response to DNA damage The Role of Structural Elements of the 5'-Terminal Region of p53 mRNA in Translation under Stress Conditions Assayed by the Antisense Oligonucleotide Approach The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition.The common stress responsive transcription factor ATF3 binds genomic sites enriched with p300 and H3K27ac for transcriptional regulation.Biphasic and Stage-Associated Expression of CPEB4 in Hepatocellular Carcinoma.Developing a Gene Biomarker at the Tipping Point of Adaptive and Adverse Responses in Human Bronchial Epithelial Cells p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses p53 Specifically Binds Triplex DNA In Vitro and in Cells p53 amplifies Toll-like receptor 5 response in human primary and cancer cells through interaction with multiple signal transduction pathways GATA4 represses an ileal program of gene expression in the proximal small intestine by inhibiting the acetylation of histone H3, lysine 27.Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation.A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements Identification of cellular senescence-specific genes by comparative transcriptomics.Integration of TP53, DREAM, MMB-FOXM1 and RB-E2F target gene analyses identifies cell cycle gene regulatory networks.Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage.Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells.Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution.p53 and NF-κB coregulate proinflammatory gene responses in human macrophages.TP53 mutants in the tower of babel of cancer progression.Indirect p53-dependent transcriptional repression of Survivin, CDC25C, and PLK1 genes requires the cyclin-dependent kinase inhibitor p21/CDKN1A and CDE/CHR promoter sites binding the DREAM complex.p53, a translational regulator: contribution to its tumour-suppressor activity.Census and evaluation of p53 target genes.Cooperative interactions between p53 and NFκB enhance cell plasticity.

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Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells.

http://www.wikidata.org/entity/Q37122075

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on 17 June 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Diverse stresses dramatically ...... ndscape in human cancer cells.

@en

Diverse stresses dramatically ...... ndscape in human cancer cells.

@nl

type

label

Diverse stresses dramatically ...... ndscape in human cancer cells.

@en

Diverse stresses dramatically ...... ndscape in human cancer cells.

@nl

prefLabel

Diverse stresses dramatically ...... ndscape in human cancer cells.

@en

Diverse stresses dramatically ...... ndscape in human cancer cells.

@nl

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Nucleic Acids Research

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Diverse stresses dramatically ...... ndscape in human cancer cells.

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Carl W Anderson

http://www.w3.org/2001/XMLSchema#string

Daniel Menendez

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Johannes M Freudenberg

http://www.w3.org/2001/XMLSchema#string

Michael A Resnick

http://www.w3.org/2001/XMLSchema#string

Raja Jothi

http://www.w3.org/2001/XMLSchema#string

Thuy-Ai Nguyen

http://www.w3.org/2001/XMLSchema#string

Viju J Mathew

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Fitting a mixture model by expectation maximization to discover motifs in biopolymers

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7286-7301

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10.1093/NAR/GKT504

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15

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41

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2013-06-17T00:00:00Z

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239734476

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23775793

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