Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis. - Wikidata - wikimedia - TriplyDB

Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

http://www.wikidata.org/entity/Q37125940

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Transforming growth factor beta1 signaling via interaction with cell surface Hyal-2 and recruitment of WWOX/WOX1 WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells Wwox-Brca1 interaction: role in DNA repair pathway choice Genetic causes of high and low serum HDL-cholesterol.WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines.Disorders of sex development: new genes, new concepts.Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiforme Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species.WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.The WWOX gene modulates high-density lipoprotein and lipid metabolism.GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells.Translational genetics for diagnosis of human disorders of sex development A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma.Roles of the WWOX in pathogenesis and endocrine therapy of breast cancer.Molecular origin of the binding of WWOX tumor suppressor to ErbB4 receptor tyrosine kinase.The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration.Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype.Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk.Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.Proteomics of osteoarthritic chondrocytes and cartilage.Common Chromosomal Fragile Site Gene WWOX in Metabolic Disorders and Tumors The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability.The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism.WWOX: a fragile tumor suppressor.WWOX, large common fragile site genes, and cancer.Genomics of Esophageal Cancer and Biomarkers for Early Detection.WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721.WWOX-related encephalopathies: delineation of the phenotypical spectrum and emerging genotype-phenotype correlation.Alternating expression levels of WWOX tumor suppressor and cancer-related genes in patients with bladder cancer.Tumor suppressor WWOX moderates the mitochondrial respiratory complex.Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells.Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions Modeling WWOX Loss of Function : What Have We Learned?

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Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis.

http://www.wikidata.org/entity/Q37125940

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 30 October 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Targeted ablation of the WW do ...... s to impaired steroidogenesis.

@en

Targeted ablation of the WW do ...... s to impaired steroidogenesis.

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type

label

Targeted ablation of the WW do ...... s to impaired steroidogenesis.

@en

Targeted ablation of the WW do ...... s to impaired steroidogenesis.

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prefLabel

Targeted ablation of the WW do ...... s to impaired steroidogenesis.

@en

Targeted ablation of the WW do ...... s to impaired steroidogenesis.

@nl

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Targeted ablation of the WW do ...... s to impaired steroidogenesis.

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Alain de Bruin

http://www.w3.org/2001/XMLSchema#string

Eugenio Gaudio

http://www.w3.org/2001/XMLSchema#string

Gary S Stein

http://www.w3.org/2001/XMLSchema#string

Hansjuerg Alder

http://www.w3.org/2001/XMLSchema#string

Hasan Siddiqui

http://www.w3.org/2001/XMLSchema#string

Jane B Lian

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Maysoon Rawahneh

http://www.w3.org/2001/XMLSchema#string

Rami I Aqeilan

http://www.w3.org/2001/XMLSchema#string

Zaidoun Salah

http://www.w3.org/2001/XMLSchema#string

P2860

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

Targeted deletion of Wwox reveals a tumor suppressor function

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth

WW and SH3 domains, two different scaffolds to recognize proline-rich ligands

Loss of WWOX expression in gastric carcinoma

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1530-1535

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scholarly article

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10.1210/EN.2008-1087

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3

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150

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Stefano Volinia

Carlo Maria Croce

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2008-10-30T00:00:00Z

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23441845

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18974271

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2654736

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