Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
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Marine Invertebrate Metabolites with Anticancer Activities: Solutions to the "Supply Problem"Combinatorial biosynthesis of polyketides--a perspective.Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin.Streamlined syntheses of (-)-dictyostatin, 16-desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-desmethyl-25,26-dihydrodictyostatinNatural product synthesis at the interface of chemistry and biology.Natural products from the Lithistida: a review of the literature since 2000.Bacterial biosynthesis and maturation of the didemnin anti-cancer agents.Improved synthesis of 6-epi-dictyostatin and antitumor efficacy in mice bearing MDA-MB231 human breast cancer xenografts.A relay ring-closing metathesis synthesis of dihydrooxasilines, precursors of (Z)-iodo olefins.Microtubule stabilising agents for cancer chemotherapy.New microtubule-inhibiting anticancer agents.Advances in the development of hybrid anticancer drugs.Leiodermatolide, a potent antimitotic macrolide from the marine sponge Leiodermatium sp.Total synthesis and biological evaluation of a series of macrocyclic hybrids and analogues of the antimitotic natural products dictyostatin, discodermolide, and taxol.Mariculture and natural production of the antitumoural (+)-discodermolide by the Caribbean marine sponge Discodermia dissoluta.SmCpR2-mediated cross-coupling of allyl and propargyl ethers with ketoesters and a telescoped approach to complex cycloheptanols.Expeditious assembly of fused dihydropyranones via N-heterocyclic carbene-catalyzed tandem Michael addition/lactonization.Highly enantioselective synthesis of fused bicyclic dihydropyranones via low-loading N-heterocyclic carbene organocatalysis.Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.
P2860
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P2860
Development of practical syntheses of the marine anticancer agents discodermolide and dictyostatin.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 27 February 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Development of practical synth ...... scodermolide and dictyostatin.
@en
Development of practical synth ...... scodermolide and dictyostatin.
@nl
type
label
Development of practical synth ...... scodermolide and dictyostatin.
@en
Development of practical synth ...... scodermolide and dictyostatin.
@nl
prefLabel
Development of practical synth ...... scodermolide and dictyostatin.
@en
Development of practical synth ...... scodermolide and dictyostatin.
@nl
P2093
P356
P1476
Development of practical synth ...... scodermolide and dictyostatin.
@en
P2093
Gordon J Florence
Ian Paterson
Nicola M Gardner
P304
P356
10.1039/B705661N
P577
2008-02-27T00:00:00Z