TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
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A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMPMurine gammaherpesvirus 68 encoding open reading frame 11 targets TANK binding kinase 1 to negatively regulate the host type I interferon responseCytoplasmic DNA innate immune pathwaysCytosolic-DNA-mediated, STING-dependent proinflammatory gene induction necessitates canonical NF-κB activation through TBK1Functional dissection of the TBK1 molecular networkVaricella-zoster virus immediate-early protein 62 blocks interferon regulatory factor 3 (IRF3) phosphorylation at key serine residues: a novel mechanism of IRF3 inhibition among herpesvirusesNoninvasive biophotonic imaging for studies of infectious disease.Mesenchymal stem cells detect and defend against gammaherpesvirus infection via the cGAS-STING pathway.Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells.Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhoodCytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37.The P Protein of Spring Viremia of Carp Virus Negatively Regulates the Fish Interferon Response by Inhibiting the Kinase Activity of TANK-Binding Kinase 1.Intracellular detection and immune signaling pathways of DNA vaccines.ELF4 is critical for induction of type I interferon and the host antiviral response.The STING pathway and regulation of innate immune signaling in response to DNA pathogens.The IKK Kinases: Operators of Antiviral Signaling.Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection.Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β.Human TBK1: A Gatekeeper of Neuroinflammation
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TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
TANK-binding kinase-1 plays an ...... onses to DNA virus infections.
@en
TANK-binding kinase-1 plays an ...... onses to DNA virus infections.
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type
label
TANK-binding kinase-1 plays an ...... onses to DNA virus infections.
@en
TANK-binding kinase-1 plays an ...... onses to DNA virus infections.
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TANK-binding kinase-1 plays an ...... onses to DNA virus infections.
@en
TANK-binding kinase-1 plays an ...... onses to DNA virus infections.
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P2093
P2860
P356
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TANK-binding kinase-1 plays an ...... ponses to DNA virus infections
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Arash Shahangian
Genhong Cheng
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P304
P356
10.4049/JIMMUNOL.0802466
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P577
2009-02-01T00:00:00Z