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Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsTargeting mechanism of the retinoblastoma tumor suppressor by a prototypical viral oncoprotein. Structural modularity, intrinsic disorder and phosphorylation of human papillomavirus E7An induced fit mechanism regulates p53 DNA binding kinetics to confer sequence specificityCrosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding14-3-3 activation of DNA binding of p53 by enhancing its association into tetramersMechanistic differences in the transcriptional activation of p53 by 14-3-3 isoformsDoes Notch play a tumor suppressor role across diverse squamous cell carcinomas?Targeting Oncogenic Mutant p53 for Cancer TherapyElectrochemistry of nonconjugated proteins and glycoproteins. Toward sensors for biomedicine and glycomicsPhysicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)Wrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsEfficient Atomistic Simulation of Pathways and Calculation of Rate Constants for a Protein-Peptide Binding Process: Application to the MDM2 Protein and an Intrinsically Disordered p53 Peptide.p53 dynamics upon response element recognition explored by molecular simulations.C-terminal substitution of MDM2 interacting peptides modulates binding affinity by distinctive mechanismsTargeted rescue of a destabilized mutant of p53 by an in silico screened drugStabilising the DNA-binding domain of p53 by rational design of its hydrophobic coreStructural evolution of p53, p63, and p73: Implication for heterotetramer formationCrystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled TetramerSystematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX InteractionsDiversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairsInteraction of the p53 DNA-Binding Domain with Its N-Terminal Extension Modulates the Stability of the p53 TetramerStructure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T CellsAcetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentrationStructure and Kinetic Stability of the p63 Tetramerization DomainPliable DNA Conformation of Response Elements Bound to Transcription Factor p63Small molecule induced reactivation of mutant p53 in cancer cellsStructure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertionStructures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescueTransient Protein States in Designing Inhibitors of the MDM2-p53 InteractionThe role of p53 in cancer drug resistance and targeted chemotherapyCold atmospheric plasma, a novel promising anti-cancer treatment modalityp53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum ConceptA versatile platform to analyze low-affinity and transient protein-protein interactions in living cells in real timeStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesTP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblastsSignificant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug TreatmentEnergetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 InteractionTracing the evolution of the p53 tetramerization domainStructure of full-length p53 tumor suppressor probed by chemical cross-linking and mass spectrometry.Missense mutation Lys18Asn in dystrophin that triggers X-linked dilated cardiomyopathy decreases protein stability, increases protein unfolding, and perturbs protein structure, but does not affect protein function.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Structural biology of the tumor suppressor p53.
@en
Structural biology of the tumor suppressor p53.
@nl
type
label
Structural biology of the tumor suppressor p53.
@en
Structural biology of the tumor suppressor p53.
@nl
prefLabel
Structural biology of the tumor suppressor p53.
@en
Structural biology of the tumor suppressor p53.
@nl
P1476
Structural biology of the tumor suppressor p53.
@en
P304
P356
10.1146/ANNUREV.BIOCHEM.77.060806.091238
P577
2008-01-01T00:00:00Z