BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1 - Wikidata - wikimedia - TriplyDB

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

http://www.wikidata.org/entity/Q37137914

about

Genetically engineered mouse models in oncology research and cancer medicine In vivo models in breast cancer research: progress, challenges and future directions.Distinct implications of different BRCA mutations: efficacy of cytotoxic chemotherapy, PARP inhibition and clinical outcome in ovarian cancer BRCA1 reversion mutation acquired after treatment identified by liquid biopsy.Reverse the Resistance to PARP Inhibitors.Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer.The BRCA1 Ubiquitin ligase function sets a new trend for remodelling in DNA repair.BRCA1 loses the ring but lords over resistance.53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1 Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A.Gene-Specific Genetic Complementation between Brca1 and Cobra1 During Mouse Mammary Gland Development.Generation of autochthonous mouse models of clear cell renal cell carcinoma: mouse models of renal cell carcinoma.RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA mutated breast cancer.Activity of HSP90 Inhibiton in a Metastatic Lung Cancer Patient With a Germline BRCA1 Mutation.Triple-negative breast cancer and the potential for targeted therapy Association of with early age onset of breast cancer patients in selected cohort from Pakistani population Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance

P2860

Q28079323-9182DCD1-661B-4997-B3FA-392D3E4EE645 Q33588117-47952708-57D0-4C98-9A43-DEABBA8B0B7A Q33704050-134C5153-0CF8-4B1F-BD7B-DBA0D2748F73 Q33869633-07E9B3CE-D8EA-4732-A3EF-460015D358B2 Q37675896-A8AF3358-9C06-4E02-AEC8-E516419B02DD Q38741192-2C2D7B8C-27D3-4888-826D-927E08B67D33 Q38798405-2276E850-FBAA-4F66-A7D8-7CDE3F4DC666 Q39062063-EC5C9AA2-6050-4A0F-B9E6-E3577F8F8735 Q41961167-0CE019D4-F3B6-4BCA-9925-FB8AB4E44677 Q42728109-43E11783-4EFD-444E-A319-3BE8596EC4D4 Q48352256-A5B1D03A-7936-4073-A6B4-013244346A38 Q49185754-29CC65AB-452E-489A-ADCE-BD6776F34449 Q49936294-BBD057F3-234D-41B1-A46C-A85470D926D5 Q52590924-D4A45313-803A-4EC9-9102-3C4B2A75F62B Q52596087-E101699A-7810-4214-90C4-18EE2653E772 Q52660676-49D64434-89D4-4826-B11C-2C9E6A53F3DC Q57115890-F64E7EB0-EECD-4E71-9A53-695C89632042 Q57822999-0E4E6C02-8868-40E3-B8C8-4E95EAC2C7E5 Q57826033-A525EAD2-5218-4D2F-8BEE-52F338C505DD Q58696749-A27DBD7B-07BE-4AB3-BF24-621841B9E949

P2860

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

http://www.wikidata.org/entity/Q37137914

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 25 July 2016

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

@en

BRCA1185delAG tumors may acqui ...... expression of RING-less BRCA1.

@nl

type

label

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

@en

BRCA1185delAG tumors may acqui ...... expression of RING-less BRCA1.

@nl

prefLabel

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

@en

BRCA1185delAG tumors may acqui ...... expression of RING-less BRCA1.

@nl

P1433

Q37137914-849CA9A2-9851-47D6-AC41-AADD9A98BC33

P1476

Q37137914-F5DF1D1D-AF55-4B91-BD0F-F7D38DD6C8F3

P2093

Q37137914-04F243A8-ED99-4D46-9CDC-70E22A50E987

Q37137914-1842F308-DAD4-4AAC-81CB-26471FF15C20

Q37137914-18954408-C198-4A42-A268-7DBE1367805F

Q37137914-1D60D272-14F3-479A-9281-75263CBB69C9

Q37137914-1DE70898-EA63-4636-A4C9-E81274277C7A

Q37137914-30624D47-5AAE-4B99-A924-0DCDFAFA8CF8

Q37137914-31812B51-9F13-4370-B04F-37895159A735

Q37137914-3C91E2E3-A83E-404F-8F2A-969FFA5D3AB4

Q37137914-3F6FF501-4192-4D1B-AEC5-F452FADE06B5

Q37137914-48AA9ED0-0CBB-4DE2-A61E-4094E8710D94

P2860

Q37137914-01E98E43-BF4D-44C5-949F-506385C81E0E

Q37137914-062DC8FC-F16F-4DFA-8992-848F5E8D11C8

Q37137914-1294456D-5224-4EC1-AF4A-618BE38795E3

Q37137914-1EDFB15F-09A5-429C-91F7-312E8B1E706A

Q37137914-20119F6F-8494-4943-85D7-B268D3DE144E

Q37137914-2763B4EC-7979-4460-AF71-FF60861D0F02

Q37137914-2A50E62F-18E9-4A94-8604-A53C67EA7F61

Q37137914-2A73161A-6802-42F6-90E4-56EAB8021B2A

Q37137914-2B6E1A35-2612-4E5C-983A-D0D3D3F00A41

Q37137914-2B92229B-1668-4518-98E5-E25240624F0E

P304

Q37137914-D1BAC796-2B39-4D6D-B52C-509A02BF78EB

P31

Q37137914-617DBD59-228A-4183-BA60-301135BB2698

P356

Q37137914-DAFDFCC2-A42E-4073-913C-D2C6B102572F

P407

Q37137914-3345E5A7-12AF-411E-94EE-2A1B40E6FA54

P433

Q37137914-A433EAFA-3F9D-4B85-970C-626E7D23370C

P478

Q37137914-E268D0F6-CA42-410B-B6B5-0F68C885EF4F

P50

Q37137914-14E72CFC-77A4-43CF-BE46-525A25B3FA4E

Q37137914-655C4D28-92FC-4FD2-A09C-1FD5C3BC65FF

Q37137914-977E8061-D7FA-4E32-A2C8-07905637AF35

Q37137914-A38F468F-9CC5-4C78-816E-C5DED85307EC

Q37137914-D3046ACB-E609-4A05-B7C9-1799EF82FF93

Q37137914-E0A6522C-3D75-4F16-853B-323A583730C2

Q37137914-E9041588-C751-4AE2-A028-E8E6DF85CE8E

Q37137914-FCC67430-5AB1-42CA-B879-8CB615C15541

P577

Q37137914-A39C8A9B-3E5A-4ED6-857F-47E4A8734E20

P698

Q37137914-CBE31483-ED41-40AA-B770-8F87DDB9688B

P932

Q37137914-FC01BAD4-0590-4E52-8357-1FC066FADE94

P356

P1433

Journal of Clinical Investigation

P1476

BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1

@en

P2093

Cristina Cruz

http://www.w3.org/2001/XMLSchema#string

Dafni Chondronasiou

http://www.w3.org/2001/XMLSchema#string

Dick H W Dekkers

http://www.w3.org/2001/XMLSchema#string

Dik C van Gent

http://www.w3.org/2001/XMLSchema#string

Eline van der Burg

http://www.w3.org/2001/XMLSchema#string

Ellen Wientjens

http://www.w3.org/2001/XMLSchema#string

Eva Schut

http://www.w3.org/2001/XMLSchema#string

Hanneke van der Gulden

http://www.w3.org/2001/XMLSchema#string

Ingrid van der Heijden

http://www.w3.org/2001/XMLSchema#string

Jos Jonkers

http://www.w3.org/2001/XMLSchema#string

P2860

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer

BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair

BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A

Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1

Activation of the E3 ligase function of the BRCA1/BARD1 complex by polyubiquitin chains

53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

Multiplex genome engineering using CRISPR/Cas systems

High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

BRCA1 is a component of the RNA polymerase II holoenzyme

BRCA1 interacts with components of the histone deacetylase complex

P304

2903-2918

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1172/JCI70196

http://www.w3.org/2001/XMLSchema#string

P407

P433

8

http://www.w3.org/2001/XMLSchema#string

P478

126

http://www.w3.org/2001/XMLSchema#string

P50

Fabricio Loayza-Puch

Christiaan Klijn

Judith Balmaña

Sven Rottenberg

P577

2016-07-25T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

27454287

http://www.w3.org/2001/XMLSchema#string

P932

4966325

http://www.w3.org/2001/XMLSchema#string