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Challenges to the clinical application of pluripotent stem cells: towards genomic and functional stabilityTrim24 targets endogenous p53 for degradationTumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signalingSmall-molecule inhibitors of the Myc oncoproteinRapamycin induces pluripotent genes associated with avoidance of replicative senescenceMitigating age-related immune dysfunction heightens the efficacy of tumor immunotherapy in aged mice.Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studiesIdentification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc.Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.Role of senescence and mitotic catastrophe in cancer therapy.The origins and evolution of the p53 family of genes.Pathologies associated with the p53 response.Paradoxical suppression of cellular senescence by p53mTOR favors senescence over quiescence in p53-arrested cells.MI-219-zinc combination: a new paradigm in MDM2 inhibitor-based therapyBladder cancer in the elderly.Exon 1 disruption alters tissue-specific expression of mouse p53 and results in selective development of B cell lymphomasZfra is a small wizard in the mitochondrial apoptosisCan microRNAs act as biomarkers of aging?Gene expression modifications in Wharton's Jelly mesenchymal stem cells promoted by prolonged in vitro culturingInflammation and p53: A Tale of Two StressesThe Regulation of Aging and Longevity: A New and Complex Role of p53.Oxidative stress-mediated apoptosis induced by ethanolic mango seed extract in cultured estrogen receptor positive breast cancer MCF-7 cells.Induction of apoptosis and oxidative stress in estrogen receptor-negative breast cancer, MDA-MB231 cells, by ethanolic mango seed extractMolecular damage in cancer: an argument for mTOR-driven agingcep-1/p53-dependent dysplastic pathology of the aging C. elegans gonad.Epigenetic control of cell cycle-dependent histone gene expression is a principal component of the abbreviated pluripotent cell cycle.p53 negatively regulates Aurora A via both transcriptional and posttranslational regulation.Association of RNF43 with cell cycle proteins involved in p53 pathway.Microarray analysis of ageing-related signatures and their expression in tumors based on a computational biology approachAdiponectin suppresses colorectal carcinogenesis under the high-fat diet conditionp53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish.Small-molecule activation of p53 blocks hypoxia-inducible factor 1alpha and vascular endothelial growth factor expression in vivo and leads to tumor cell apoptosis in normoxia and hypoxiaDominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs.High expression of fibronectin is associated with poor prognosis, cell proliferation and malignancy via the NF-κB/p53-apoptosis signaling pathway in colorectal cancer.Aging is not programmed: genetic pseudo-program is a shadow of developmental growth.Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase.Interference with p53 functions in human viral infections, a target for novel antiviral strategies?Deregulation of the cell cycle machinery by Epstein-Barr virus nuclear antigen 3C.New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The tumor suppressor p53: cancer and aging.
@en
The tumor suppressor p53: cancer and aging.
@nl
type
label
The tumor suppressor p53: cancer and aging.
@en
The tumor suppressor p53: cancer and aging.
@nl
prefLabel
The tumor suppressor p53: cancer and aging.
@en
The tumor suppressor p53: cancer and aging.
@nl
P356
P1433
P1476
The tumor suppressor p53: cancer and aging.
@en
P2093
Gunaretnam Rajagopal
Zhaohui Feng
P304
P356
10.4161/CC.7.7.5657
P577
2008-01-23T00:00:00Z