p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics. - Wikidata - wikimedia - TriplyDB

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

http://www.wikidata.org/entity/Q37142159

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Mast cell activation: a complex interplay of positive and negative signaling pathways Rho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular trafficking p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils Remodelling of cortical actin where lytic granules dock at natural killer cell immune synapses revealed by super-resolution microscopy Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation p21-Activated kinase inhibitors: a patent review PAK signalling during the development and progression of cancer p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization.Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells P21-activated kinase in inflammatory and cardiovascular disease.Nf1-/- Schwann cell-conditioned medium modulates mast cell degranulation by c-Kit-mediated hyperactivation of phosphatidylinositol 3-kinase.Inhibition of p21 activated kinase (PAK) reduces airway responsiveness in vivo and in vitro in murine and human airways.Republished: tracing PAKs from GI inflammation to cancer Potential compensation among group I PAK members in hindlimb ischemia and wound healing.Adapters in the organization of mast cell signaling.Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells Identification of the atypical MAPK Erk3 as a novel substrate for p21-activated kinase (Pak) activity Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway.PAK1 as a therapeutic target.Inhibition or ablation of p21-activated kinase (PAK1) disrupts glucose homeostatic mechanisms in vivo.Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP Mast cells in airway diseases and interstitial lung disease p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.Pak2 kinase restrains mast cell FcεRI receptor signaling through modulation of Rho protein guanine nucleotide exchange factor (GEF) activity.Suppression of FoxO6 by lipopolysaccharide in aged rat liver.Functional integrity of the T-tubular system in cardiomyocytes depends on p21-activated kinase 1 Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cells.A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases.Group I p21-activated kinases: emerging roles in immune function and viral pathogenesis.The p21-activated kinase (PAK1) is involved in diet-induced beta cell mass expansion and survival in mice and human islets.Cytoskeleton in mast cell signaling.Mouse models of PAK function.Herbal therapeutics that block the oncogenic kinase PAK1: a practical approach towards PAK1-dependent diseases and longevity.p21-Activated protein kinases and their emerging roles in glucose homeostasis.P21 activated kinases: structure, regulation, and functions.

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p21-activated kinase regulates mast cell degranulation via effects on calcium mobilization and cytoskeletal dynamics.

http://www.wikidata.org/entity/Q37142159

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article científic

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artigo científico

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bilimsel makale

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scientific article published on 05 January 2009

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vedecký článok

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vědecký článek

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name

p21-activated kinase regulates ...... ion and cytoskeletal dynamics.

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BLOOD-2008-06-160861

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Andrew McDaniel

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Clemens Hofmann

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D Wade Clapp

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David A Ingram

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Elizabeth G Michels

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Ethel Derr-Yellin

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Jayme D Allen

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Mary Ann Sells

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Sarah Burgin

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Shi Chen

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P2860

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

p21-activated kinases in cancer

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo

Localized activation of p21-activated kinase controls neuronal polarity and morphology

RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells

Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

Temporal and spatial distribution of activated Pak1 in fibroblasts

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2695-2705

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10.1182/BLOOD-2008-06-160861

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12

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Jonathan Chernoff

Jeffrey B Travers

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19124833

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